Residential proximity to major roads and placenta/birth weight ratio
Residential proximity to major roads and placenta/birth weight ratio
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住宅靠近主要道路和胎盘/出生体重比
DOI：
10.1016/j.scitotenv.2011.11.001
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Kawachi I
中科院分区：
文献类型：
--
作者：
Yorifuji T;Naruse H;Kashima S;Murakoshi T;Tsuda T;DOI: H;Kawachi I
暴露于空气污染已被证明会增加早产和低出生体重的风险。我们研究了靠近主要道路（作为暴露于空气污染的标志）是否与胎盘/出生体重比增加（作为胎盘运输功能的生物标志）有关。父母特征和出生结果的数据提取自日本静冈县一家大医院维护的数据库。我们将分析限制在1997年至2008年间活产单胎的母亲（n=14,189）。利用地理编码的居住信息，根据与主要道路的距离对每次出生进行分类。我们使用多元线性回归检验了靠近主要道路与胎盘/出生体重比之间的关系。靠近主要道路与较高的胎盘/出生体重比相关。在对潜在混杂因素进行调整后，居住在主干道200米以内的居民使这一比例增加了0.48% （95% CI=0.15至0）。80)。此外，靠近主要道路与胎盘重量和出生体重较低有关。这些观察到的关联在靠近主要道路的参与者中更强。接触与交通有关的空气污染与较高的胎盘/出生体重比有关。胎盘氧和营养物质运输功能受损可能是解释空气污染与低出生体重和早产之间存在关联的机制。
Exposure to air pollution has been demonstrated to increase the risk of preterm birth and low birth weight. We examined whether proximity to major roads (as a marker of exposure to air pollution) is associated with increased placenta/birth weight ratio (as a biomarker of the placental transport function). Data on parental characteristics and birth outcomes were extracted from the database maintained by a major hospital in Shizuoka Prefecture, Japan. We restricted the analysis to mothers who delivered liveborn single births from 1997 to 2008 (n=14,189). Using geocoded residential information, each birth was classified according to proximity to major roads. We examined the association between proximity to major roads and the placenta/birth weight ratio, using multiple linear regression. Proximity to major roads was associated with higher placenta/birth weight ratio. After adjusting for potential confounders, living within 200m of a major road increased the ratio by 0.48% (95% CI=0.15 to 0. 80). In addition, proximity to major roads was associated with lower placenta weight and birth weight. These observed associations were stronger among participants living closer to major roads. Exposure to traffic-related air pollution is associated with higher placenta/birth weight ratio. Impaired placental oxygen and nutrient transport function might be a mechanism for explaining the observed association between air pollution and low birth weight as well as preterm birth.