Celebrating the 30th anniversary of a pioneering microfluidics paper.
Celebrating the 30th anniversary of a pioneering microfluidics paper.
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庆祝开创性微流体论文发表 30 周年。
DOI：
10.1039/d3lc90076b
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发表时间：
2023
期刊：
影响因子：
6.1
通讯作者：
Harrison,DJed
中科院分区：
文献类型：
--
作者：
Fan,ZHugh;Harrison,DJed
今年，我们纪念 Harrison 等人在《科学》杂志上发表论文 30 周年。 1 通常因帮助建立微流体学作为一个研究领域以及在学术界、工业界和政府机构中普及该学科而受到赞誉。在论文中，作者描述了一种微加工方法，用于制造两个玻璃器件，以进行电渗泵浦和电泳分离，而当时的微加工主要针对传统半导体基板硅。虽然之前已经发表了使用微型泵和阀门开发微系统的努力，但使用传统机制制造高质量泵的挑战极大地限制了系统的开发。 1993 年的《科学》论文展示了一种替代技术，该技术允许对分析程序（样品注入、分离和检测）进行实质性集成，展示了芯片实验室概念的前景，并实际上引入了“芯片实验室”一词。这篇开创性论文的影响部分体现在根据科睿唯安科学网的超过 1500 次引用（或根据谷歌学术搜索超过 2600 次引用）。图1显示了从1993年到2023年每年引用该论文的出版物数量，表明该论文在发表的第一个十年中影响力迅速上升，在第二个十年中持续影响。
This year we mark the 30th anniversary of the Science paper by Harrison et al. 1 that is often credited for helping establish microfluidics as a research field and for popularizing the subject in academia, industry and governmental agencies. In the paper, the authors described a microfabrication method that was used to make two glass devices to carry out electroosmotic pumping and electrophoretic separation, while micromachining at that time was primarily for silicon, a traditional semiconductor substrate. While efforts to develop microsystems using microfabricated pumps and valves had been previously published, the challenge of making quality pumps using conventional mechanisms greatly limited system development. The 1993 Science paper demonstrated an alternative technology that allowed substantial integration of analytical procedures (sample injection, separation, and detection), showing the promise of the lab-on-a-chip concept, and in fact introducing the phrase, laboratory on a chip.The impact of this pioneering paper is partially indicated by its> 1500 citations according to Clarivate's Web of Science (or> 2600 citations according to Google Scholar). Fig. 1 shows the number of publications citing the paper in each year from 1993 to 2023, indicating its rapidly escalating impact during the first decade of its publication and continuous influence in the second decade.