CHEMICAL CHARACTERIZATION OF A FAMILY OF BRAIN LIPIDS THAT INDUCE SLEEP
CHEMICAL CHARACTERIZATION OF A FAMILY OF BRAIN LIPIDS THAT INDUCE SLEEP
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DOI：
10.1126/science.7770779
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发表时间：
1995-06-09
期刊：
影响因子：
56.9
通讯作者：
LERNER, RA
中科院分区：
文献类型：
--
作者：
CRAVATT, BF;PROSPEROGARCIA, O;LERNER, RA
从睡眠剥夺的猫的脑脊液中分离的分子已被化学表征并鉴定为顺式-9，10-十八碳烯酰胺。除顺式-9，10-十八碳烯酰胺外，其他脂肪酸伯酰胺也被鉴定为猫、大鼠和人脑脊液的天然成分，表明这些化合物组成了一个独特的脑脂质家族。合成的顺式-9，10-十八碳烯酰胺注射到大鼠体内后可诱导生理性睡眠。总之，这些结果表明，脂肪酸伯酰胺可能代表了以前未被认识到的一类生物信号分子。
A molecule isolated from the cerebrospinal fluid of sleep-deprived cats has been chemically characterized and identified as cis-9,10-octadecenoamide. Other fatty acid primary amides in addition to cis-9,10-octadecenoamide were identified as natural constituents of the cerebrospinal fluid of cat, rat, and human, indicating that these compounds compose a distinct family of brain lipids. Synthetic cis-9,10-octadecenoamide induced physiological sleep when injected into rats. Together, these results suggest that fatty acid primary amides may represent a previously unrecognized class of biological signaling molecules.