Effects of ghrelin on sepsis-induced acute kidney injury: one step forward
Effects of ghrelin on sepsis-induced acute kidney injury: one step forward
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DOI：
10.1007/s10157-014-1006-x
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发表时间：
2015-06-01
影响因子：
2.3
通讯作者：
Sharawy, Nivin
中科院分区：
文献类型：
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作者：
Khowailed, Akef;Younan, Sandra Mourad;Sharawy, Nivin
在脓毒症引起的几种疾病中，急性肾损伤（AKI）是最重要的经济负担问题，具有高死亡率和高发病率。本研究旨在探讨胃饥饿素在败血症性AKI中的抗炎作用及其在迷走神经中的可能作用。分为5组：假手术、盲肠结扎穿刺（CLP）组、CLP-胃饥饿素组、CLP-迷走神经切开术组和CLP-迷走神经切开术-胃饥饿素组。与未受保护的CLP组相比，在CLP诱导后立即使用Ghrelin治疗，肾小球滤过率（GFR）、血清肌酐、BUN和肾坏死评分均显著提高。此外，ghrelin显著降低肾脏TNF - α (111.5 +/- A 10.35 vs. 291.8 +/- A 15.8 pg/mg ptn)、VCAM1 （6.28 +/- A 1.7 vs. 12.9 +/- A 1.2 A mu/g ptn）和MPO (0.95 +/- A 0.13 vs. 2.5 +/- A 0.4 A mu/g ptn)，但肾脏IL-10无显著升高。迷走神经切开术消除了这些影响。我们得出结论，胃饥饿素可能是脓毒症诱导AKI早期治疗的新治疗窗口，这可能主要是由于其抗炎作用。
Among the several disorders induced by sepsis, acute kidney injury (AKI) represents the most important economic burden problem that is associated with high mortality and morbidity rates. The aim of this study was to investigate the anti-inflammatory effects of ghrelin in sepsis-induced AKI and the possible role of vagus nerve.Five groups were included: sham, cecal ligation and puncture (CLP), CLP-ghrelin, CLP-vagotomy and CLP-vagotomy-ghrelin group.Ghrelin treatment immediately after induction of CLP, significantly improved renal Glomerular filtration rate (GFR), serum creatinine, BUN and renal necrosis score as compared to the unprotected CLP group. In addition, ghrelin significantly decreased renal TNF alpha (111.5 +/- A 10.35 vs. 291.8 +/- A 15.8 pg/mg ptn), VCAM1 (6.28 +/- A 1.7 vs. 12.9 +/- A 1.2 A mu/g ptn) and MPO (0.95 +/- A 0.13 vs. 2.5 +/- A 0.4 A mu/g ptn) without significant increase in renal IL-10. Those effects were abolished by vagotomy.We concluded that ghrelin could represent new therapeutic window in early treatment of sepsis-induced AKI and this could be mainly due to its anti-inflammatory effects.