Persistent dyspnea complaints at long-term follow-up after an episode of acute pulmonary embolism: Results of a questionnaire
Persistent dyspnea complaints at long-term follow-up after an episode of acute pulmonary embolism: Results of a questionnaire
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DOI：
10.1016/j.ejim.2008.02.006
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发表时间：
2008-12-01
影响因子：
8
通讯作者：
Huisman, M. V.
中科院分区：
文献类型：
--
作者：
Klok, F. A.;Tijmensen, J. E.;Huisman, M. V.
背景资料：有一个缺乏资料的长期并发症的患者与肺栓塞（PE），包括慢性投诉的呼吸困难。方法：concentive患者与先前诊断的急性PE和年龄和性别匹配的对照组，没有病史的PE提出了一份问卷，旨在建立存在，严重程度和可能的原因呼吸困难的临床过程中的PE。结果：在PE后40 +/- 7.4个月对48名PE幸存者进行了问卷调查; 27名患者（56%）主诉呼吸困难。16例（35%）被归类为NYHA II级，6例（13%）被归类为III级，5例（10%）被归类为IV级。总体而言，19例患者（70%）在PE后出现新发或恶化的投诉。该研究包括61个对照组。校正性别、年龄和病史后，对照组的呼吸困难明显少于PE幸存者（p < 0.001）。校正性别和年龄后，NYHA II级患者的发生率为4倍（OR 3.6 95%CI 1.4-9.7），NYHA分级患者的发生率为7倍。III级或IV级（OR 6.5 95%CI 1.7-24），均与对照subjects.Conclusion：一个很大的比例的患者与先前的PE有持续的投诉，呼吸困难在长期随访。他们中的大多数在血栓栓塞事件后出现新发或恶化的呼吸困难。与没有静脉血栓栓塞病史的对照人群相比，肺栓塞患者的呼吸困难总体上明显更严重。对这种现象的解释需要在这些患者的进一步功能检查中进行研究。(C)2008年欧洲内科联盟。Elsevier B. V.出版版权所有
Background: There is a lack of information on long term complications of patients with pulmonary embolism (PE), including chronic complaints of dyspnea.Methods: Consecutive patients with a prior diagnosis of acute PE and an age and gender matched control group with no medical history of PE were presented with a questionnaire, designed to establish the presence, severity and possible causes of dyspnea in the clinical Course of PE.Results: The questionnaire was taken in 48 PE-survivors 40 +/- 7.4 months after PE; 27 patients (56%) had complaints of dyspnea. Sixteen (35%) were categorized as NYHA class II, 6 (13%) as class III and 5 (10%) as class IV. Overall, 19 patients (70%) had new or worsened complaints after PE. The study included 61 controls. Corrected for gender, age and medical history, the control group was significantly less dyspnoeic compared to the PE survivors (p < 0.001). Corrected for gender and age, patients were 4 times more often in NYHA class II (OR 3.6 95%CI 1.4-9.7) and 7-fold more often in NYHA. class III or IV (OR 6.5 95%CI 1.7-24), both compared to control subjects.Conclusion: A large percentage of patients with prior PE have persistent complaints of dyspnea at long term follow-up. The majority of them developed new or worsened dyspnea after the thrombo-embolic event. In comparison to a control population without a medical history of VTE, PE patients were overall significantly more dyspnoeic. An explanation for this phenomenon needs to be studied in further functional work-up of these patients. (C) 2008 European Federation of Internal Medicine. Published by Elsevier B.V. All rights