Association between C-Reactive Protein and Adiposity in Women
Association between C-Reactive Protein and Adiposity in Women
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DOI：
10.1210/jc.2008-2428
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发表时间：
2009-10-01
影响因子：
5.8
通讯作者：
Rousson, Valentin
中科院分区：
文献类型：
--
作者：
Bochud, Murielle;Marquant, Fabienne;Rousson, Valentin
内容：C-反应蛋白（CRP）和肥胖之间的联系值得进一步探讨，考虑到有争议的糖尿病的作用CRP.Objective：我们探讨了潜在的因果关系CRP对措施的adiposity.Design：我们使用了孟德尔随机化的方法与CRP和LEPR基因作为工具变量在一个跨部门的高加索人群为基础的研究，包括2526名男性和2836名女性。结果：CRP基因rs7553007单核苷酸多态性与BMI显著相关[回归系数：1.22（0.18; 2.25），P = 0.02]和脂肪量[2.67（0.65; 4.68），P = 0.01]，但在女性中与瘦体重无关，而在男性中未发现相关性。由rs 1805096 LEPR单核苷酸多态性解释的对数转换CRP也与BMI或脂肪量呈正相关，尽管不显著。CRP-LEPR组合工具分别解释了女性和男性CRP变异的2.24%和0.77%。通过该组合工具解释的对数转换CRP与BMI显著相关[0.98（0.32; 1.63），P = 0.004]，脂肪量[2.07（0.79; 3.34），P = 0.001]和腰围[2.09（0.39; 3.78），P = 0.01]。结论：我们的数据表明，CRP是因果关系和正相关的BMI在妇女中，这主要是由于脂肪质量。联合CRP-LEPR仪器的结果表明，瘦素可能在女性CRP和肥胖之间的因果关系中发挥作用。男性的结果不显著。（临床内分泌代谢杂志94：3969-3977，2009）
Context: The link between C-reactive protein (CRP) and adiposity deserves to be further explored, considering the controversial diabetogenic role of CRP.Objective: We explored the potential causal role of CRP on measures of adiposity.Design: We used a Mendelian randomization approach with the CRP and LEPR genes as instrumental variables in a cross-sectional Caucasian population-based study comprising 2526 men and 2836 women. Adiposity was measured using body mass index (BMI), fat and lean mass estimated by bioelectrical impedance, and waist circumference.Results: Log-transformed CRP explained by the rs7553007 single-nucleotide polymorphism tagging the CRP gene was significantly associated with BMI [regression coefficient: 1.22 (0.18; 2.25), P = 0.02] and fat mass [2.67 (0.65; 4.68), P = 0.01] but not with lean mass in women, whereas no association was found in men. Log-transformed CRP explained by the rs1805096 LEPR single-nucleotide polymorphism was also positively associated, although not significantly, with BMI or fat mass. The combined CRP-LEPR instrument explained 2.24 and 0.77% of CRP variance in women and men, respectively. Log-transformed CRP explained by this combined instrument was significantly associated with BMI [0.98 (0.32; 1.63), P = 0.004], fat mass [2.07 (0.79; 3.34), P = 0.001], and waist [2.09 (0.39; 3.78), P = 0.01] in women but not men.Conclusion: Our data suggest that CRP is causally and positively related to BMI in women and that this is mainly due to fat mass. Results on the combined CRP-LEPR instrument suggest that leptin may play a role in the causal association between CRP and adiposity in women. Results in men were not significant. (J Clin Endocrinol Metab 94: 3969-3977, 2009)