Antibody avidity, persistence, and response to antigen recall: comparison of vaccine adjuvants.
Antibody avidity, persistence, and response to antigen recall: comparison of vaccine adjuvants.
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抗体亲合力、持久性和对抗原回忆的反应：疫苗佐剂的比较。
DOI：
10.1038/s41541-021-00337-0
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发表时间：
2021-05-21
期刊：
影响因子：
9.2
通讯作者：
Burny W
中科院分区：
文献类型：
--
作者：
Budroni S;Buricchi F;Cavallone A;Bourguignon P;Caubet M;Dewar V;D'Oro U;Finco O;Garçon N;El Idrissi M;Janssens M;Leroux-Roels G;Marchant A;Schwarz T;Van Damme P;Volpini G;van der Most R;Didierlaurent AM;Burny W
疫苗佐剂之间先天免疫“印记”的差异可能介导对持续适应性反应的数量/质量的不同影响。我们比较了含有佐剂系统（AS）01B、AS01E、AS03、AS04或Alum （NCT00805389）的乙型肝炎疫苗在免疫后1年（Day [D]360）给予非佐剂分次剂量抗原的抗体亲和力成熟、抗体/记忆B细胞/CD4+ T细胞反应持久性和召回反应。抗体和B细胞水平在峰值反应、D360和抗原召回后增加（D390）时排名相似（AS01B/E/AS03 > AS04 > Alum）。在所有组中，高亲和力抗体的比例在剂量2后均有所增加，并在D360时持续存在，但与明矾相比，AS似乎更强烈地促进了亲和力成熟。抗原回忆后，只有在AS组中，高亲和力抗体受试者的频率显著增加。其中，AS04的总抗体应答最低。然而，各组之间的高亲和抗体比例相似，表明AS04的MPL有助于亲和成熟。AS中免疫增强剂的特异性组合，无论其个体性质如何，都可以增加抗体的持久性和贪婪性成熟。
Differences in innate immune ‘imprinting’ between vaccine adjuvants may mediate dissimilar effects on the quantity/quality of persisting adaptive responses. We compared antibody avidity maturation, antibody/memory B cell/CD4+ T cell response durability, and recall responses to non-adjuvanted fractional-dose antigen administered 1-year post-immunization (Day [D]360), between hepatitis B vaccines containing Adjuvant System (AS)01B, AS01E, AS03, AS04, or Alum (NCT00805389). Both the antibody and B cell levels ranked similarly (AS01B/E/AS03 > AS04 > Alum) at peak response, at D360, and following their increases post-antigen recall (D390). Proportions of high-avidity antibodies increased post-dose 2 across all groups and persisted at D360, but avidity maturation appeared to be more strongly promoted by AS vs. Alum. Post-antigen recall, frequencies of subjects with high-avidity antibodies increased only markedly in the AS groups. Among the AS, total antibody responses were lowest for AS04. However, proportions of high-avidity antibodies were similar between groups, suggesting that MPL in AS04 contributes to avidity maturation. Specific combinations of immunoenhancers in the AS, regardless of their individual nature, increase antibody persistence and avidity maturation.
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影响因子：
3
作者：
Ajua, Anthony;Lell, Bertrand;Mordmueller, Benjamin
通讯作者：
Mordmueller, Benjamin
影响因子：
7.3
作者：
Burny, Wivine;Callegaro, Andrea;Didierlaurent, Arnaud M.
通讯作者：
Didierlaurent, Arnaud M.
影响因子：
5.5
作者：
Burny, Wivine;Marchant, Arnaud;Yarzabal, Juan Pablo
通讯作者：
Yarzabal, Juan Pablo
DOI：
10.4161/hv.7.12.18282
发表时间：
2011-12-01
期刊：
HUMAN VACCINES
影响因子：
--
作者：
Einstein, Mark H.;Baron, Mira;Descamps, Dominique
通讯作者：
Descamps, Dominique
影响因子：
5.4
作者：
Alexander, Marina R.;Ringe, Rajesh;Klasse, Per Johan
通讯作者：
Klasse, Per Johan