The Value of Serum α-Fetoprotein in Predicting Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma
The Value of Serum α-Fetoprotein in Predicting Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma
复制标题
DOI：
10.1007/s10620-008-0349-0
复制
发表时间：
2009-02-01
影响因子：
3.1
通讯作者：
Zheng, Shu-Sen
中科院分区：
文献类型：
--
作者：
Xu, Xiao;Ke, Qing-Hong;Zheng, Shu-Sen
背景 许多接受肝移植（LT）的肝细胞癌（HCC）患者随后出现肿瘤复发；这是影响LT后长期生存的主要因素。应确定与肿瘤复发相关的因素以改善 LT 的结果。该研究的目的是评估甲胎蛋白 (AFP) 在预测 HCC 患者 LT 后肿瘤复发方面的价值。方法回顾性分析我中心97例接受LT治疗的HCC患者LT前后的AFP数据。结果所有97例患者的平均随访时间为17.1±2.1个月，总体肿瘤复发率为32.9%（32/97），平均复发时间为7.2±3.2个月。最常见的肿瘤复发部位是肝脏、肺、骨骼等部位。移植前 AFP 水平 >400 ng/ml 与较高的肿瘤复发相关。移植后 AFP 水平未降低至
Background Many patients with hepatocellular carcinoma (HCC) who undergo liver transplantation (LT) subsequently develop tumor recurrence; this is the main factor affecting long-term survival after LT. Factors associated with tumor recurrence should be determined to improve the outcome of LT. The purpose of the study was to evaluate the value of alpha-fetoprotein (AFP) in forecasting tumor recurrence after LT for patients with HCC. Methods AFP data before and after LT for 97 patients with HCC who underwent LT in our center were analyzed retrospectively. Results The mean follow-up time was 17.1 +/- 2.1 months for all 97 patients, overall tumor recurrence rate was 32.9% (32/97), and mean recurrence time was 7.2 +/- 3.2 months. The most common tumor recurrence sites were liver, lung, skeleton, and other sites. Pre-transplant AFP levels >400 ng/ml were associated with higher tumor recurrence. Post-transplant AFP levels not decreasing to