Analytical modeling of laser pulse heating of embedded biological targets: An application to cutaneous vascular lesions
Analytical modeling of laser pulse heating of embedded biological targets: An application to cutaneous vascular lesions
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DOI：
10.1063/1.2200592
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发表时间：
2006-06
影响因子：
3.2
通讯作者：
Mirko G. Mirkov;Evan A. Sherr;R. Sierra;J. Lloyd;E. Tanghetti
中科院分区：
文献类型：
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作者：
Mirko G. Mirkov;Evan A. Sherr;R. Sierra;J. Lloyd;E. Tanghetti
详细了解接受激光照射的生物目标的热过程仍然是一个具有挑战性的问题。例如，当代脉冲染料激光器（PDL）提供复杂的脉冲格式，这对理论理解和进一步发展提出了特定的挑战。数值方法可以充分描述热过程，但缺乏阐明激光参数的影响。这项工作的目的是导出一个简化的分析模型，可以指导未来激光器设计的开发。开发了组织中加热和冷却过程的数学模型。当应用于热源的特定时间和空间分布时，可以找到模型的精确解析解。解决方案被简化为简单的代数表达式。提出了一种算法，用于通过具有精确解的类型的热源来近似激光加热皮肤结构的实际情况。简单的代数表达式...
Detailed understanding of the thermal processes in biological targets undergoing laser irradiation continues to be a challenging problem. For example, the contemporary pulsed dye laser (PDL) delivers a complex pulse format which presents specific challenges for theoretical understanding and further development. Numerical methods allow for adequate description of the thermal processes, but are lacking for clarifying the effects of the laser parameters. The purpose of this work is to derive a simplified analytical model that can guide the development of future laser designs. A mathematical model of heating and cooling processes in tissue is developed. Exact analytical solutions of the model are found when applied to specific temporal and spatial profiles of heat sources. Solutions are reduced to simple algebraic expressions. An algorithm is presented for approximating realistic cases of laser heating of skin structures by heat sources of the type found to have exact solutions. The simple algebraic expressio...