Supramolecular hydrogels inspired by collagen for tissue engineering
Supramolecular hydrogels inspired by collagen for tissue engineering
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DOI：
10.1039/c002609c
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发表时间：
2010-01-01
影响因子：
3.2
通讯作者：
Yang, Zhimou
中科院分区：
文献类型：
--
作者：
Hu, Yuehan;Wang, Huaimin;Yang, Zhimou
超分子水凝胶是一种在二维和三维环境中进行细胞培养的有前途的生物材料。受胶原蛋白的化学结构的启发，它带有甘氨酸-Xaa-4 R-羟脯氨酸（GXO; Xaa是任何一种天然氨基酸）的重复三肽，我们设计并合成了一个小的超分子水凝胶因子库（共6个）。我们发现四种水凝胶适合于NIH 3 T3细胞在2-D环境中培养。凝胶2是最好的水凝胶，具有与用于3 T3细胞培养的胶原相似的性质。这些发现不仅为组织工程提供了更多的超分子水凝胶候选物，而且为设计模拟自然的生物材料提供了新的策略。
Supramolecular hydrogels are promising biomaterials for cell culture in 2-D and 3-D environments. Inspired by the chemical structure of collagen, which bears the repeating tripeptide of glycine-Xaa-4R-hydroxyproline (GXO; Xaa is any one of the natural amino acids), we designed and synthesized a small library of supramolecular hydrogelators (a total of 6). We found that four of the hydrogels were suitable for NIH 3T3 cell culture in the 2-D environments. Gel 2, the best hydrogel, has properties that are similar to those of collagen for 3T3 cell culture. These findings not only provide more supramolecular hydrogel candidates for tissue engineering, but also offer a new strategy for designing biomaterials that mimic nature.