O59 MRI methods to define colonic function in health and constipation
O59 MRI methods to define colonic function in health and constipation
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O59 MRI 方法定义健康和便秘中的结肠功能
DOI：
10.1136/gutjnl-2020-bsgcampus.59
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Wilkinson-Smith V
中科院分区：
文献类型：
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作者：
Wilkinson-Smith V
RECLAIM是一项多中心研究，检查功能性便秘（FC）和IBS伴便秘（IBS-C）患者，以及沿着健康志愿者（HV），以将MRI结果与结肠测压结果和临床反应相关联。我们进行了一项中期分析的MRI数据收集到目前为止，以评估结肠反应的渗透性泻药患者便秘和health.MethodsParticipants招募两个网站被分为健康志愿者（HV），便秘为主的IBS（IBS-C）或功能性便秘（FC）的基础上罗马IV criteria.A空腹基线扫描进行使用3 T飞利浦Ingenia扫描仪。然后，参与者服用MoviPrepTM，并在60分钟和120分钟时进行两次扫描。MRI测量包括：结肠体积、通过时间（使用前一天获取的通过标记物的加权平均位置分数0-7;较高分数=较慢通过）和结肠内容物混合的度量（标记为对运动敏感的MRI数据中的%变异系数，在感兴趣的上行结肠区域上平均）。图像分析对受试者的情况不知情，基线和最大值用于考虑不同的口盲转运和研究中期排便情况。从MoviPrepTM到第一次排便（TBM）的时间记录使用截止时间为150分钟（平均时间花费在中心）。ResultsTo date，66名参与者完成了MRI（31 HV，年龄和性别匹配23 IBS-C和12 FC：结果在表1中列出）。与IBS-C和HV相比，在MoviPrepTM治疗后，FC组的体积和较基线的增加最大。运输评分和TBM是可变的，但与HV相比，患者组的运输较慢。虽然混合减少患者相比，HV这是不显着的。ConclusionThe MoviPrepTM挑战，如前所述，表现出较大的结肠和便秘患者的传输速度较慢相比，健康，现在可以用来量化在临床实践中的异常功能。
BackgroundRECLAIM is a multicentre study examining patients with functional constipation (FC) and IBS with constipation (IBS-C), along with healthy volunteers (HV) to correlate MRI findings with those from colonic manometry, and clinical response. We performed an interim analysis of MRI data collected so far to assess the colonic response to an osmotic laxative in patients with constipation and health.MethodsParticipants recruited across two sites were classified as healthy volunteers (HV), constipation-predominant IBS (IBS-C) or functional constipation (FC) based on ROME IV criteria.A fasting baseline scan was performed using a 3T Philips Ingenia scanner. Participants then consumed MoviPrepTMand had two further scans at 60 and 120 mins. MRI measures included: colonic volume, transit time (using the weighted-average position score 0–7 of transit markers taken the previous day; higher scores = slower transit) and a metric of mixing of colonic contents (% coefficient of variance in MRI data tagged to give sensitivity to movement, averaged over ascending colon region of interest). Image analysis was performed blind to participant condition.Baseline and maximum value reached were used to allow for different oral-caecal transit and mid-study defaecation. Time from MoviPrepTMto first bowel movement (TBM) was recorded using a cut off at 150 min (average time spent at centre).ResultsTo date, 66 participants have completed MRI (31 HVs, age and gender matched to 23 IBS-C and 12 FC: results outlined in table 1). After MoviPrepTM, largest volumes and increase from baseline was seen in the FC group compared to IBS-C and HV. Transit scores and TBM were variable but showed slower transit for the patient groups compared to HV. Whilst mixing decreased in patients compared to HV this was not significant.ConclusionThe MoviPrepTMchallenge, as previously reported, demonstrates larger colons and slower transit in patients with constipation compared to health and could now be used to quantify abnormal function in clinical practice.