Transforming growth factor alpha and epidermal growth factor levels in normal human gastrointestinal mucosa.
Transforming growth factor alpha and epidermal growth factor levels in normal human gastrointestinal mucosa.
复制标题
正常人胃肠道粘膜中转化生长因子α和表皮生长因子水平。
DOI：
10.1038/bjc.1989.334
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发表时间：
1989-11
影响因子：
8.8
通讯作者：
Elder, J B
中科院分区：
文献类型：
--
作者：
Cartlidge, S A;Elder, J B
从4例正常成人器官供体的23例正常人胃肠道粘膜中提取酸溶性蛋白，并进行转化生长因子α（TGF α）和尿抑胃素表皮生长因子（URO-EGF）的特异性放射免疫分析。发现所有组织都含有免疫反应性TGF α，水平范围为57至4，776 pg-1组织湿重。尽管组织供体之间的水平不同，但在所有情况下，TGF α在整个胃肠道中的分布似乎相似。尿EGF水平低得多（0-216 pg g-1湿重）。7岁女性供体胃肠道粘膜提取物中的TGF α水平较高，观察到的分布与成人水平明显不同。在该患者的粘膜或粘膜下组织提取物中未检测到URO-EGF。需要对青少年进行进一步研究。
Acid soluble proteins from 23 samples of normal human gastrointestinal mucosa derived from four normal adult organ donors were extracted and subjected to specific radiommunoassays for transforming growth factor alpha (TGF alpha) and urogastrone epidermal growth factor (URO-EGF). All tissues were found to contain immunoreactive TGF alpha and levels ranged from 57 to 4,776 pg-1 wet weight of tissue. Although levels varied between tissue donors, the distribution of TGF alpha throughout the gastrointestinal tract appeared similar in all cases. URO-EGF levels were much lower (0-216 pg g-1 wet weight). TGF alpha levels in extracts of gastrointestinal mucosa from a 7-year-old female donor were higher and the observed distribution was markedly different from adult levels. URO-EGF was not detected in mucosal or submucosal tissue extracts from this patient. Further studies in juveniles are indicated.