Uptake Decrease of Proliferative PET Tracer (18) FLT in Bone Marrow after Carbon Ion Therapy in Lung Cancer
Uptake Decrease of Proliferative PET Tracer (18) FLT in Bone Marrow after Carbon Ion Therapy in Lung Cancer
复制标题
肺癌碳离子治疗后骨髓中增殖 PET 示踪剂 (18) FLT 的摄取减少
DOI：
10.1007/s11307-010-0363-4
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发表时间：
2011
期刊：
影响因子：
3.1
通讯作者：
Koizumi M
中科院分区：
文献类型：
--
作者：
Kitamura N;Araki K;Kosuda S;Tomifuji M;Shiotani A;Shigematsu N;Fujii H;Koizumi M
目的研究非小细胞肺癌患者接受碳离子放射治疗（CIRT）前后正常骨髓（BM）中18氟脱氧胸苷（18FLT）摄取的变化。根据放射计划计算放射剂量。结果18FLT摄取在>10%照射区明显降低，在<10%照射区轻度降低; CIRT后18FLT摄取最低，3个月时略有升高，1年以上无变化。结论18 FLT提示小剂量CIRT如<4.2-4.4 GyE/1分次可引起BM功能下降，>4.2 - 4.4 GyE/1分次可使BM功能恢复。
PurposeThe aim of this study was to investigate the change of 3′-[18F]fluoro-3′-deoxy-l-thymidine (18FLT) uptake in normal bone marrow (BM) after inevitable radiation.ProceduresTwenty-one non-small cell lung cancer patients who received carbon ion radiotherapy (CIRT) were studied with18FLT-positron emission tomography/computed tomography (PET/CT) at pre- and post-CIRT. Radiation dose was calculated by radiation planning. Irradiated BM was divided into three groups (<10% of maximum dose, 10–30%, and >30%).Results18FLT uptake clearly decreased at >10% irradiated areas and mildly decreased at <10% areas.18FLT uptake was lowest just after CIRT, somewhat increased at 3 months, and remained unchanged for more than 1 year. There was no significant difference between 10–30% and >30% areas.Conclusion18FLT revealed that BM function decreased by small dose such as <4.2–4.4 GyE/1 fraction of CIRT and is eradicated by >4.2–4.4 GyE/1 fraction.