Microfabricated Cortical Neuroprostheses
Microfabricated Cortical Neuroprostheses
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微型皮质神经假体
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
P. Renaud
中科院分区：
文献类型：
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作者：
A. Mercanzini;P. Renaud
使用神经植入物进行刺激和记录显示了在恢复中枢神经系统某些功能方面的良好前景；神经假体仍然是神经科学家阐明大脑功能的最重要工具之一。帕金森氏症、肥胖、失明和癫痫等疾病就是从这个角度进行研究的。因此，开发更好的记录和刺激电极对于确保这一领域的持续进展至关重要。这本书阐述了使用电极的主要临床并发症之一，即植入设备附近的神经组织的反应。作者描述了评估这一现象的新技术，以及阻止大脑炎症反应的新微制造技术。炎症会对这些设备产生不利影响，限制其使用寿命并降低其有效性。这些页面中描述的测量方案和改进的制造方案将成为未来神经假体的标准工具。
The use of neural implants for stimulation and recording show excellent promise in restoring certain functions to the central nervous system; and neuroprostheses remains one of the most important tools of neuroscientists for the elucidation of the brain's function. Ailments such as Parkinson's disease, obesity, blindness, and epilepsy are being studied from this angle. Development of better electrodes for recording and stimulation is therefore critical to ensure continuing progress in this field. This book addresses one of the main clinical complications with the use of electrodes, namely the reaction of the neurological tissue in the immediate vicinity of an implanted device. The authors describe new techniques for assessing this phenomenon, as well as new microfabrication techniques to impede the inflammatory response of the brain. Inflammation can adversely effect these devices, limiting their lifetime and reducing their effectiveness. The measurement protocols and improved fabrication protocols described within these pages will become standard tools in the future of neuroprostheses.