MicroRNAs: Game Changers in the Regulation of -Synuclein in Parkinson's Disease
MicroRNAs: Game Changers in the Regulation of -Synuclein in Parkinson's Disease
复制标题
MicroRNA：帕金森病中突触核蛋白调节的游戏规则改变者
DOI：
10.1155/2019/1743183
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Wang Zhiqin
中科院分区：
文献类型：
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作者：
Zhao Liang;Wang Zhiqin
Parkinson’s disease (PD) is the second most common neurodegenerative disorder. Its neuropathological hallmarks include neuronal loss in the substantia nigra pars compacta (SNpc) and the presence of Lewy bodies containing aggregates ofα‐synuclein (α‐syn). An imbalance between the rates ofα‐syn synthesis, aggregation, and clearance can result in abnormalα‐syn levels and contribute to the pathogenesis of PD. MicroRNAs (miRNAs) are endogenous single‐stranded noncoding RNAs (∼22 nucleotides) that have recently emerged as key posttranscriptional regulators of gene expression. In this review, we summarize the functions of miRNAs that directly targetα‐syn. We also review miRNAs that indirectly impactα‐syn levels or toxicity through different pathways, including those involved in the clearance ofα‐syn and neuroinflammation.
