Editorial comment: Reduction of oxidative stress: a new indication for acetylsalicylic acid in coronary artery bypass surgery.
Editorial comment: Reduction of oxidative stress: a new indication for acetylsalicylic acid in coronary artery bypass surgery.
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编辑评论：减少氧化应激：乙酰水杨酸在冠状动脉搭桥手术中的新适应症
DOI：
10.1093/ejcts/ezs614
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Moser M
中科院分区：
文献类型：
--
作者：
Diehl P;Olivier C;Bode C;Moser M
21世纪初，冠状动脉疾病（CAD）的治疗方案仍在快速发展。除经皮冠状动脉介入治疗外，冠状动脉旁路移植术（CABG）是有症状的 CAD 患者的基本治疗方法，2007-08 年美国每年每百万成年人进行了 1081 例 CABG 手术[1]。由于其抗血小板作用，乙酰水杨酸 (ASA) 治疗对于 CAD 患者至关重要，并已被证明可通过改善移植物通畅性对 CABG 后患者有益 [2]。然而，ASA 会增加接受 CABG 手术的患者术后出血并发症的风险，因此术前 ASA 停用的时机一直存在争议 [3]。 过去十年越来越多的证据表明，抗血小板药物不仅会损害血小板聚集，而且还能减少全身炎症和氧自由基的产生 [4, 5]。最近的研究表明，CABG 通常与损害术后患者预后的全身氧化应激和连续炎症有关，因此出现了 ASA 是否能减少接受 CABG 手术的患者围术期全身炎症从而改善术后预后的问题 [6]。
Treatment options for coronary artery disease (CAD) are still undergoing rapid development in the early 21st century. Besides percutaneous coronary intervention, coronary artery bypass grafting (CABG) is the fundamental treatment of symptomatic CAD patients with 1081 CABG surgeries per million adults per year in 2007–08 in the USA [1]. Due to its antiplatelet effect, acetylsalicylic acid (ASA) treatment is of vital importance in CAD patients and has been proven to be beneficial for patients after CABG by improving graft patency [2]. However, ASA carries the risk of increased postoperative bleeding complications in patients undergoing CABG operations, and the timing of preoperative ASA discontinuation has therefore been discussed controversially [3].An increasing body of evidence has shown over the last decade that antiplatelet drugs not only impair platelet aggregation, but furthermore, reduce systemic inflammation and oxygen radical production [4, 5]. As recent studies have shown that CABG is often associated with systemic oxidative stress and consecutive inflammation impairing the postoperative patient outcome, the question has arisen whether ASA reduces perioperative, systemic inflammation in patients undergoing CABG operations and thereby improves the postoperative outcome [6].
影响因子：
120.7
作者：
Epstein, Andrew J.;Polsky, Daniel;Yang, Feifei;Yang, Lin;Groeneveld, Peter W.
通讯作者：
Groeneveld, Peter W.
影响因子：
24
作者：
Smith, Peter K.;Goodnough, Lawrence T.;Levy, Jerrold H.;Poston, Robert S.;Short, Mary A.;Weerakkody, Govinda J.;LeNarz, LeRoy A.
通讯作者：
LeNarz, LeRoy A.
影响因子：
9.5
作者：
Diehl, Philipp;Olivier, Christoph;Moser, Martin
通讯作者：
Moser, Martin