Aluminum increases cyclic AMP in rat cerebral cortex in vivo.
Aluminum increases cyclic AMP in rat cerebral cortex in vivo.
复制标题
铝可增加大鼠体内大脑皮层的环磷酸腺苷。
DOI：
10.1016/0024-3205(86)90192-x
复制
发表时间：
1986
期刊：
影响因子：
6.1
通讯作者：
Jope,RS
中科院分区：
文献类型：
--
作者：
Johnson,GV;Jope,RS
通过两种途径中的任一种给予柠檬酸铝的大鼠的大脑皮层中的环AMP的体内浓度升高;在饮食中一个月或通过实验前两周的单次脑室内注射。这些治疗并没有改变在体内的环GMP或乙酰胆碱的浓度。铝处理也改变了皮质环磷酸腺苷的匹鲁卡品和阿扑吗啡的管理。有人提出，铝的神经毒性是不是由于对乙酰胆碱的影响，但可能是由于改变蛋白磷酸化作为一个结果的环AMP的慢性升高。
In vivo concentrations of cyclic AMP were elevated in the cerebral cortex of rats that were administered aluminum citrate by either of two routes; in the diet for one month or via a single intracerebroventricular injection two weeks prior to the experiment. These treatments did not alter the in vivo concentrations of cyclic GMP or acetylcholine. Aluminum treatment also altered the response of cortical cyclic AMP to the administration of pilocarpine and of apomorphine. It is proposed that the neurotoxicity of aluminum is not due to effects on acetylcholine but may be due to altered protein phosphorylation as a consequence of the chronic elevation of cyclic AMP.