A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity
A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity
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DOI：
10.1038/onc.2016.24
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Jinke Cheng
中科院分区：
文献类型：
--
作者：
Juan Cai;Juwei Mou;Yong Zuo;Tianshi Wang;Ying Cao;Rong Cai;Jinke Cheng
Sirt6 is a histone deacetylase with NAD+-dependent activity. Sirt6 has been shown as a tumor suppressor partially via inhititing the expression of c-Myc target genes and ribosome biogenesis. However, how to regulate Sirt6 activity is largely unknown. In this study, we identify that Sirt6 can be modified by small ubiquitin-like modifier. Sirt6 SUMOylation deficiency specifically decreases its deacetylation of H3K56 but not H3K9 in vivo. Mechanistically, we find that SUMOylation deficiency decreases Sirt6 binding with c-Myc, decreasing Sirt6 occupancy on the locus of c-Myc target genes. Therefore, Sirt6 SUMOylation deficiency reduces its deacetylation of H3K56 and its repression of c-Myc targer genes. Moreover, Sirt6 SUMOylation deficiency reduces its suppression of deacetylation on H3K56, as well as its tumor suppressive activity.
