LONGITUDINAL-STUDY OF SALT PREFERENCES IN NORMOTENSIVE AND HYPERTENSIVE RATS
LONGITUDINAL-STUDY OF SALT PREFERENCES IN NORMOTENSIVE AND HYPERTENSIVE RATS
复制标题
DOI：
10.1161/01.hyp.7.3_pt_1.326
复制
发表时间：
1985-01-01
期刊：
影响因子：
8.3
通讯作者：
GRAY, SD
中科院分区：
文献类型：
--
作者：
FERRELL, F;GRAY, SD
为了确定自发性高血压大鼠（SHR）和Wistar-Kyoto大鼠（WKY）的寿命中是否会发生与年龄相关的盐偏好变化，对每种基因型的相同动物在幼年、幼年和老年时进行了测试。NaCl和KCl在0.001-1.0 M浓度下的味觉偏好比，通过对每种盐与蒸馏水进行24小时、2瓶的偏好测试来计算。基因型对NaCl和KCl的偏好均有显著影响（P < 0.0005）。在每个年龄和不同浓度，SHR始终比WKY有更高的偏好。两种菌株对NaCl的总体偏好几乎没有明显的年龄相关变化，但幼虫和成年SHR和WKY对低于排斥阈值的较高浓度的NaCl表现出比年轻成虫更强的偏好（P < 0.001）。SHR中KCl的浓度偏好趋势统计年龄与NaCl相似。然而，年轻成人WKY对该化合物的排斥阈值明显低于青少年和老年人（P < 0.001）。基因型、年龄、盐型和盐浓度可相互作用影响高血压患者的盐偏好。
To determine whether age-related changes in salt preferences occur over the lifespans of spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY), the same animals of each genotype were tested as juveniles, and as young and older adults. Taste preference ratios for NaCl and KCl, at concentrations from 0.001-1.0 M, were calculated using 24-h, 2-bottle preference tests of each salt vs. distilled water. Genotype exerted a significant effect on preference for both NaCl and KCl (P < 0.0005). At each age and across concentrations, SHR had consistently higher preferences than did WKY. Few marked, age-related changes in overall preferences for NaCl were noted within either strain, but juvenile and older adult SHR and WKY exhibited stronger preferences than did young adults for the higher concentrations of NaCl below the rejection threshold (P < 0.001). Statistical age by concentration preference trends for KCl were similar to those for NaCl in SHR. Young adult WKY, however, had a significantly lower rejection threshold for that compound than did juveniles and older adults (P < 0.001). Genotype, age, salt type and salt concentration can interact to influence salt preference in hypertension.