When killers become helpers.
When killers become helpers.
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DOI：
10.1016/j.it.2007.03.005
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发表时间：
2007-05
影响因子：
16.8
通讯作者：
J. Hanna;O. Mandelboim
中科院分区：
文献类型：
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作者：
J. Hanna;O. Mandelboim
自Kiessling在35年前首次对其进行表征以来，自然杀伤（NK）细胞继续构成免疫学领域的密集发现领域。虽然大多数研究工作集中在表征NK细胞在肿瘤预防和通过杀死危险细胞对抗感染中的作用，但最近的几项发现突出了人类和小鼠NK细胞的非细胞溶解功能。这些功能包括促进胎盘组织发育、抗原呈递和刺激T细胞、引发巨噬细胞和树突状细胞、减少移植组织排斥反应等。
Since their initial characterization by Kiessling over 35 years ago, natural killer (NK) cells continue to constitute an area of intensive discovery in the immunology field. Although most of the research efforts concentrated on characterizing the role of NK cells in tumor prevention and fighting infection through the killing of dangerous cells, several recent findings highlight unexpected non-cytolytic functions of human and mouse NK cells. Such functions include promoting placental tissue development, antigen presentation and stimulation of T cells, priming of macrophages and dendritic cells, reducing transplant tissue rejection and several others.