Chemical lesion of the bed nucleus of the stria terminalis blocks the behavioral consequences of uncontrollable stress
Chemical lesion of the bed nucleus of the stria terminalis blocks the behavioral consequences of uncontrollable stress
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DOI：
10.1037/0735-7044.118.2.443
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发表时间：
2004-04-01
影响因子：
1.9
通讯作者：
Maier, SF
中科院分区：
文献类型：
--
作者：
Hammack, SE;Richey, KJ;Maier, SF
不可控或不可避免的休克（IS）会产生行为变化，其特征是敏感的恐惧系统和战斗-逃跑反应的缺陷。这些行为变化被认为代表了一种由压力源的不可控性产生的焦虑样状态。终纹床核（BNST）参与了对不可预测的压力源的长时间反应的调解，这也被认为是焦虑的表现。在本研究中，BNST化学损伤的影响，是诱导的冷冻致敏的环境中先前配对的休克和IS诱导的逃逸反应的损害进行了研究。BNST化学损伤阻断增强冻结和逃避潜伏期的增加，通常遵循IS。
Uncontrollable or inescapable shock (IS) produces behavioral changes that are characterized by a sensitized fear system and a deficit in fight-flight responding. These behavioral changes have been argued to represent an anxiety-like state produced by the uncontrollability of the stressor. The bed nucleus of the stria terminalis (BNST) has been implicated in the mediation of long-duration responses to unpredictable stressors, which have also been argued to represent anxiety. In the present study, the effects of BNST chemical lesion on the IS-induced sensitization of freezing to an environment previously paired with shock and the IS-induced impairment of escape responding were investigated. BNST chemical lesion blocked the potentiation of freezing and the increases in escape latency that normally follow IS.