Survivors of childhood cancer in the United States: prevalence and burden of morbidity.
Survivors of childhood cancer in the United States: prevalence and burden of morbidity.
复制标题
DOI：
10.1158/1055-9965.epi-14-1418
复制
发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
Mariotto AB
中科院分区：
文献类型：
--
作者：
Phillips SM;Padgett LS;Leisenring WM;Stratton KK;Bishop K;Krull KR;Alfano CM;Gibson TM;de Moor JS;Hartigan DB;Armstrong GT;Robison LL;Rowland JH;Oeffinger KC;Mariotto AB
没有研究估计儿童时期(0-19岁)被诊断为癌症的个人的发病率负担。我们更新了截至2011年儿童癌症幸存者的患病率估计，并更新了这一人群的发病率负担，反映为慢性病、神经认知功能障碍、与健康相关的生活质量受损和健康状况(一般健康、精神健康、功能障碍、功能限制、疼痛和恐惧/焦虑)。1975年至2011年的监测流行病学和最终结果计划数据被用来更新美国儿童癌症幸存者的患病率。儿童癌症幸存者研究数据被用来获得发病率负担指标的估计，然后将其外推到SEER数据以获得人口水平的估计。截至2011年1月1日，美国估计有388,501名儿童癌症幸存者，其中83.5%是诊断后5年的≥。≥5年幸存者中任何慢性病的患病率从66%(5-19岁)到88%(40-49岁)不等。对特定发病率的估计从12%(疼痛)到35%(神经认知功能障碍)。一般来说，发病率随着年龄的增长而增加。然而，自确诊以来，心理健康和焦虑保持相对稳定，神经认知功能障碍表现出最初的下降，然后随着时间的推移保持稳定。儿童癌症幸存者的估计患病率正在增加，这些≥患者在确诊后5年的发病率估计也在增加。应优先努力了解如何有效降低发病率负担，并纳入有效的护理、协调和康复模式，以优化这一人群的长寿和福祉。
No studies have estimated the population-level burden of morbidity in individuals diagnosed with cancer as children (ages 0-19 years). We updated prevalence estimates of childhood cancer survivors as of 2011 and burden of morbidity in this population reflected by chronic conditions, neurocognitive dysfunction, compromised health-related quality of life and health status (general health, mental health, functional impairment, functional limitations, pain and fear/anxiety). Surveillance Epidemiology and End Results Program data from 1975 to 2011 were used to update the prevalence of survivors of childhood cancers in the US. Childhood Cancer Survivor Study data were used to obtain estimates of morbidity burden indicators which were then extrapolated to SEER data to obtain population-level estimates. There were an estimated 388,501 survivors of childhood cancer in the US as of January 1, 2011, of whom 83.5% are ≥5 years post-diagnosis. The prevalence of any chronic condition among ≥5-year survivors ranged from 66% (ages 5-19) to 88% (ages 40-49). Estimates for specific morbidities ranged from 12% (pain) to 35% (neurocognitive dysfunction). Generally, morbidities increased by age. However, mental health and anxiety remained fairly stable and neurocognitive dysfunction exhibited initial decline and then remained stable by time since diagnosis. The estimated prevalence of survivors of childhood cancer is increasing, as is the estimated prevalence of morbidity in those ≥5 years post-diagnosis. Efforts to understand how to effectively decrease morbidity burden and incorporate effective care coordination and rehabilitation models to optimize longevity and well-being in this population should be a priority.