ALPHA-1-ADRENORECEPTOR AND ALPHA-2-ADRENORECEPTOR ANTAGONISTS DIFFERENTIALLY INFLUENCE LOCOMOTOR AND STEREOTYPED BEHAVIOR INDUCED BY D-AMPHETAMINE AND APOMORPHINE IN THE RAT
ALPHA-1-ADRENORECEPTOR AND ALPHA-2-ADRENORECEPTOR ANTAGONISTS DIFFERENTIALLY INFLUENCE LOCOMOTOR AND STEREOTYPED BEHAVIOR INDUCED BY D-AMPHETAMINE AND APOMORPHINE IN THE RAT
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DOI：
10.1007/bf02180034
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发表时间：
1988-01-01
影响因子：
3.4
通讯作者：
TULLOCH, IF
中科院分区：
文献类型：
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作者：
DICKINSON, SL;GADIE, B;TULLOCH, IF
多巴胺(DA)在调节啮齿动物的运动、探索和刻板行为方面的重要性已得到充分证实。证据也表明去甲肾上腺素(NA)的调节作用，尽管由于以前可用药物的非特异性，确切的作用仍未确定。研究了特异性和选择性的α-肾上腺素受体拮抗剂咪唑克生(α2)和哌唑嗪(α1)对苯丙胺和阿朴吗啡诱导的大鼠行为的影响。D-苯丙胺(2 mg/kg)可诱导大鼠过度活动和探索。预先给予哌唑嗪(1 mg/kg)可显著降低上述反应。相比之下，咪唑克生(20 mg/kg)的预处理仅略微改变了d-苯丙胺的过度活动。阿朴吗啡(0.5 mg/kg)诱导大鼠双相运动和探索活动。两种α-拮抗剂均不影响起始期(60分钟)，但哌唑嗪抑制，而咪唑克生增强第二阶段(90-180分钟)。在较高剂量下，安非他明(6 mg/kg)和阿朴吗啡(2 mg/kg)可引起刻板印象行为。哌唑嗪可增加咬合的刻板行为，减少嗅觉和运动，而咪唑生则增加运动和减少安非他明诱导的嘴巴运动。这些数据表明，多巴胺诱导的运动和刻板行为受到α1和α2肾上腺素受体拮抗剂的不同影响(方向相反)。因此，NA可能通过影响某些脑区的DA功能来调节行为的表达和特征。
The importance of dopamine (DA) in mediating locomotor, exploratory and stereotyped behaviour in rodents is well established. Evidence also indicates a modulatory role for noradrenaline (NA) although, due to nonspecificity of previously available agents, a precise role remains undefined. The effects of the specific and selective .alpha.-adrenoreceptor antagonists idazoxan (.alpha.2) and prazosin (.alpha.1) on behaviour induced by amphetamine and apomorphine have been investigated in the rat. d-Amphetamine (2 mg/kg) induced hyperactive locomotion and exploration. Pretreatment with prazosin (1 mg/kg) markedly reduced these responses. In contrast, pretreatment with idazoxan (20 mg/kg) only marginally altered d-amphetamine hyperactivity. Apomorphine (0.5 mg/kg) induced biphasic locomotor and exploratory activity. Neither .alpha.-antagonist affected the initial burst of activity (60 min), although prazosin inhibited whereas idazoxan potentiated the secondary phase (90-180 min). At higher dosage, amphetamine (6 mg/kg) and apomorphine (2 mg/kg) induced stereotyped behaviours. Prazosin pretreatment enhanced stereotyped gnawing and decreased sniffing and locomotion, whereas idazoxan increased locomotion and decreased amphetamine-induced mouth movements. These data indicate that DA-induced locomotor and stereotyped behaviours are differentially influenced (in opposite directions) by both .alpha.1-and .alpha.2-adrenoreceptor antagonists. NA may thus modulate the expression and character of behaviour by influencing DA function in certain brain areas.