A recovery from enhancement of activation in auditory cortex of patients with idiopathic sudden sensorineural hearing loss
A recovery from enhancement of activation in auditory cortex of patients with idiopathic sudden sensorineural hearing loss
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DOI：
10.1016/j.neures.2007.01.010
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发表时间：
2007-05-01
影响因子：
2.9
通讯作者：
Ito, J.
中科院分区：
文献类型：
--
作者：
Morita, T.;Hiraumi, H.;Ito, J.
Objective: We previously reported enhanced activation of auditory cortex in patients with bilateral chronic inner-ear hearing loss. To determine whether this enhancement can exhibit a short-term alteration, we measured auditory evoked magnetic fields (AEFs) in patients with idiopathic sudden sensorineural hearing loss (ISSHL) in the acute phase (AP) and recovery phases (RPs).Methods: We recorded AEFs in two unilateral ISSHL patients at three time points (AP, RP1, and RP2) using a whole-head neuromagnetometer. Tone bursts of 1 kHz were presented monaurally to the affected and healthy ear at four different intensities (40-70 dB HL).Results: Both patients showed the enhancement of N100 m moment at AP and not at RPs in response to the affected ear stimulation, and stronger N100 m moment in ipsilateral than contralateral hemisphere in response to the healthy ear stimulation at ARConclusions: Enhancement of N100 m amplitude occurs in ISSHL patients and disappears on the scale of days. Enhancement of activity in the auditory cortex derived from inner-ear hearing loss can thus exhibit short-term change.Significance: The results of this study provide first evidence for a recovery from enhancement of activation in the auditory cortex following injury of peripheral hearing organ. (c) 2007 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
