Distinct signaling pathways regulate TLR2 co-stimulatory function in human T cells.
Distinct signaling pathways regulate TLR2 co-stimulatory function in human T cells.
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DOI：
10.1016/j.cellsig.2012.11.026
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发表时间：
2013-03
影响因子：
4.8
通讯作者：
Houtman JC
中科院分区：
文献类型：
--
作者：
Chapman NM;Bilal MY;Cruz-Orcutt N;Knudson C;Madinaveitia S;Light J;Houtman JC
toll样受体2 （TLR2）通过增强T细胞受体（TCR）诱导的细胞因子的产生和增殖，作为人类T细胞的共刺激受体。然而，尚不清楚来自TCR和TLR2的信号在何处汇聚以增强T细胞的激活。为了解决这一差距，我们研究了TLR2在人类T细胞中同时激活后tcr诱导的信号传导的变化。TCR和TLR2共激活均未增强近端TCR介导的信号传导和早期NFκB激活，这可能是由于TLR2与TLR10的关联。相反，TLR2共诱导确实增强了人T细胞中Akt和Erk1/Erk2的激活。这些发现表明，TLR2激活人类T细胞中不同的信号通路，并提示TLR2共受体表达的改变可能导致异常的T细胞反应。
Toll-like receptor 2 (TLR2) serves as a co-stimulatory receptor for human T cells by enhancing T cell receptor (TCR)-induced cytokine production and proliferation. However, it is unknown where signals from the TCR and TLR2 converge to enhance T cell activation. To address this gap, we examined changes in TCR-induced signaling following concurrent TLR2 activation in human T cells. Both proximal TCR-mediated signaling and early NFκB activation were not enhanced by TCR andTLR2 co-activation, potentially due to the association of TLR2 with TLR10. Instead, TLR2 co-induction did augment Akt and Erk1/Erk2 activation in human T cells. These findings demonstrate that TLR2 activates distinct signaling pathways in human T cells and suggest that alterations in expression of TLR2 co-receptors may contribute to aberrant T cell responses.
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影响因子：
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作者：
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通讯作者：
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