COMPARISON OF IMPEDANCE TO INSULIN-MEDIATED GLUCOSE UPTAKE IN NORMAL SUBJECTS AND IN SUBJECTS WITH LATENT DIABETES
COMPARISON OF IMPEDANCE TO INSULIN-MEDIATED GLUCOSE UPTAKE IN NORMAL SUBJECTS AND IN SUBJECTS WITH LATENT DIABETES
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DOI：
10.1172/jci106433
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发表时间：
1970-01-01
影响因子：
15.9
通讯作者：
FARQUHAR, JW
中科院分区：
文献类型：
--
作者：
SHEN, SW;REAVEN, GM;FARQUHAR, JW
设计了一种技术，用于比迄今为止更准确地测量糖尿病复杂综合征中引起高血糖症的因素之一。该因子称为阻抗，代表组织对胰岛素介导的葡萄糖摄取的不敏感性或抵抗性。通过在内源性胰岛素分泌的药理学抑制期间使用稳态外源性胰岛素和葡萄糖输注来测量。内源性新葡萄糖的产生也受到抑制。计算的阻抗是稳态葡萄糖浓度的直接函数，因为所有研究中的外源性胰岛素浓度相似。研究了两组正常体重的受试者。一个患有成熟期潜伏性糖尿病，另一个（年龄、体重和肥胖率匹配）正常。阻抗在同一个体中具有密切的重现性，并且在长时间输注期间保持相对恒定。糖尿病患者的平均输注葡萄糖浓度（以及阻抗）比正常组高68%，并且值得注意的是，他们先前测量的葡萄糖不耐受的差异程度相似;即，糖尿病患者的不耐受（由口服葡萄糖后的平均加权血浆葡萄糖反应定义）比正常个体高52%。
A technique was devised for a more accurate measurement than has been heretofore possible of one of the factors responsible for hyperglycemia in the complex syndrome of diabetes. This factor is termed impedance and represents the tissues' insensitivity or resistance to insulin-mediated glucose uptake. It was measured by use of steady-state exogenous insulin and glucose infusions during a period of pharmacological suppression of endogenous insulin secretion. Endogenous new glucose production was also inhibited. Impedance as calculated is a direct function of steady-state glucose concentrations, since exogenous insulin concentrations were similar in all studies. Two groups of normal weight subjects were studied. One had maturity onset latent diabetes, and the other (matched for age, weight, and per cent adiposity) was normal. Impedance was closely reproducible in the same individual and remained relatively constant during prolonged infusions. The diabetics had average infusion glucose concentrations (and thus impedance) 68% higher than the normal group, and it is of note that their previously measured glucose intolerance differed by a similar degree; that is, the diabetic's intolerance (as defined by mean weighted plasma glucose response after oral glucose) was 52% greater than that of the normal individuals.