CsrA modulates luxR transcript levels in Vibrio fischeri.

CsrA modulates luxR transcript levels in Vibrio fischeri.
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DOI:
10.1111/j.1574-6968.2012.02499.x
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发表时间:
2012-04
影响因子:
2.1
通讯作者:
Stevens AM
Stevens AM
中科院分区:
生物学4区
文献类型:
--
作者:
Williams JW;Ritter AL;Stevens AM

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Vibrios的群体感应和CsrA调节子控制生长期间重叠的细胞功能。因此,可能存在的调节网络之间的相互作用的途径,使他们能够协调控制。在霍乱弧菌中,CsrA间接调节群体感应信号通路中LuxO的活性。在这项研究中,它被证明,在费氏弧菌,CsrA导致增加的转录水平的下游群体感应调节基因,luxR,这并不存在于霍乱弧菌系统。在费氏弧菌中,由CsrA引起的luxR转录物的增加不依赖于LitR转录激活因子,CsrA效应似乎也不通过全局调节因子cAMP-CRP发生。因此,似乎有一个以上的机制,CsrA和群体感应途径整合在弧菌的监管输出。
The quorum-sensing and CsrA regulons of Vibrios control overlapping cellular functions during growth. Hence, the potential exists for regulatory network interactions between the pathways that enable them to be coordinately controlled. In Vibrio cholerae, CsrA indirectly modulates the activity of LuxO in the quorum-sensing signaling pathway. In this study, it was demonstrated that in Vibrio fischeri, CsrA causes an increase in the transcript levels of a downstream quorum-sensing regulatory gene, luxR, which does not exist in the V. cholerae system. In V. fischeri, the increase in luxR transcripts caused by CsrA does not depend on the LitR transcriptional activator nor does the CsrA effect seem to occur through the global regulator cAMP-CRP. Thus there appears to be more than one mechanism whereby the CsrA and quorum-sensing pathways integrate regulatory outputs in Vibrios.
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