Interleukin-7 Availability Is Maintained by a Hematopoietic Cytokine Sink Comprising Innate Lymphoid Cells and T Cells
Interleukin-7 Availability Is Maintained by a Hematopoietic Cytokine Sink Comprising Innate Lymphoid Cells and T Cells
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DOI：
10.1016/j.immuni.2017.07.005
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发表时间：
2017-07-18
期刊：
影响因子：
32.4
通讯作者：
Surh, Charles D.
中科院分区：
文献类型：
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作者：
Martin, Christopher E.;Spasova, Darina S.;Surh, Charles D.
白介素7(IL-7)的可获得性决定了静息T细胞池的大小和增殖状态。然而，调节稳态IL-7水平的机制尚不清楚。使用实验性淋巴细胞减少小鼠模型和IL-7诱导的稳态增殖来测量IL-7在体内的可用性，我们发现抗辐射细胞是CD4(+)和CD8(+)T细胞的IL-7的来源。造血系细胞虽然与IL-7的来源无关，但主要负责通过其IL-7R的表达来限制IL-7的可用性。出乎意料的是，先天淋巴样细胞被发现对初级和次级淋巴组织中的IL-7含量有很大的影响。这些结果表明，IL-7的动态平衡是通过天然免疫细胞和获得性免疫细胞的多个亚群消耗来实现的。
Interleukin-7 (IL-7) availability determines the size and proliferative state of the resting T cell pool. However, the mechanisms that regulate steady-state IL-7 amounts are unclear. Using experimental lymphopenic mouse models and IL-7-induced homeostatic proliferation to measure IL-7 availability in vivo, we found that radioresistant cells were the source of IL-7 for both CD4(+) and CD8(+) T cells. Hematopoietic lineage cells, although irrelevant as a source of IL-7, were primarily responsible for limiting IL-7 availability via their expression of IL-7R. Unexpectedly, innate lymphoid cells were found to have a potent influence on IL-7 amounts in the primary and secondary lymphoid tissues. These results demonstrate that IL-7 homeostasis is achieved through consumption by multiple subsets of innate and adaptive immune cells.