Comparative Effects of a New Nicotinamide Nitrate Derivative, Nicorandil (SG 75), with Nifedipine and Nitroglycerin on True Collateral Blood Flow Following an Acute Coronary Occlusion in Dogs
Comparative Effects of a New Nicotinamide Nitrate Derivative, Nicorandil (SG 75), with Nifedipine and Nitroglycerin on True Collateral Blood Flow Following an Acute Coronary Occlusion in Dogs
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新型硝酸烟酰胺衍生物尼可地尔 (SG 75) 与硝苯地平和硝酸甘油对犬急性冠状动脉闭塞后真实侧支血流的影响比较
DOI：
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发表时间：
1984
影响因子：
3
通讯作者：
G. Gross
中科院分区：
文献类型：
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作者：
K. Lamping;G. Gross
在麻醉犬左前降支（LAD）冠状动脉急性闭塞后，研究了尼可地尔（NC）、硝苯地平（NF）和硝酸甘油（GTN）对真实侧支血流的影响。缺血组织样本被正常区域的重叠血流污染，通过使用特殊的球囊储库技术进行放射性微球给药来消除。每种药物对真实侧支血流量的影响在冠状动脉闭塞1小时后用放射性微球技术和侧支灌注的间接指数逆行压力测定。NC（25 μg/kg/min，静脉注射），NF（1.0 μg/kg/min，静脉注射），GTN（1.5 μg/kg/min，i.v.）输注降低平均动脉压和左心室收缩压相似（10-20 mm Hg）。在主动脉血压降低的情况下，这些药物对真实侧支血流没有任何影响。然而，当使用胸降主动脉周围的袖带维持主动脉压时，通过微球技术测量的NC和NF增加侧支血流以及逆行压力。此外，NC产生了显着增加，心内膜下血流，这导致心内膜-心外膜血流比（endo/epi）的增加。GTN对侧支功能的任何指标均无显著影响。这些结果表明主动脉压在确定血管扩张剂对冠状动脉侧支功能的影响方面的重要性。此外，当低血压最小化时，NC可能比NF或GTN对侧支血流具有更理想的作用，因为这是选择性增加内膜下血流的唯一药剂。
The effects of nicorandil (NC), nifedipine (NF), and nitroglycerin (GTN) on true collateral blood flow were studied following an acute occlusion of the left anterior descending (LAD) coronary artery in anesthetized dogs. Ischemic tissue samples contaminated with overlap blood flow from the normal region were eliminated by using a special balloon reservoir technique for administration of radioactive microspheres. The effects of each drug on true collateral blood flow were determined following 1 h of coronary occlusion with the radioactive microsphere technique and an indirect index of collateral perfusion, retrograde pressure. NC (25 μg/kg/min, i.v.), NF (1.0 μg/kg/min, i.v.), and GTN (1.5 μg/kg/min, i.v.) infusions reduced mean arterial and left ventricular systolic pressures similarly (10–20 mm Hg). None of the drugs had any effect on true collateral blood flow in the presence of a decrease in aortic blood pressure. However, when aortic pressure was maintained by use of a cuff around the descending thoracic aorta, NC and NF increased collateral flow as measured by the microsphere technique as well as retrograde pressure. In addition, NC produced a significant increase in subendocardial blood flow, which resulted in an increase in the endocardial-epicardial blood flow ratio (endo/epi). GTN had no significant effect on any index of collateral function. These results indicate the importance of aortic pressure in determining the effects of vasodilators on coronary collateral function. Furthermore, NC may have more desirable effects on collateral blood flow than NF or GTN when hypotension is minimized, since this was the only agent that selectively increased subendocardial blood flow.