Correlates of High HIV Viral Load and Antiretroviral Therapy Adherence Among Viremic Youth in the United States Enrolled in an Adherence Improvement Intervention.
Correlates of High HIV Viral Load and Antiretroviral Therapy Adherence Among Viremic Youth in the United States Enrolled in an Adherence Improvement Intervention.
复制标题
参与依从性改善干预措施的美国病毒血症青年中高 HIV 病毒载量与抗逆转录病毒治疗依从性的相关性。
DOI：
10.1089/apc.2021.0005
复制
发表时间：
2021
影响因子：
4.9
通讯作者：
Hudgens,Michael
中科院分区：
文献类型：
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作者：
Amico,KRivet;Crawford,Jessica;Ubong,Ini;Lindsey,JaneC;Gaur,AdityaH;Horvath,Keith;Goolsby,Rachel;MuellerJohnson,Megan;Dallas,Ronald;Heckman,Barbara;Filipowicz,Teresa;Polier,Melissa;Rupp,BettyM;Hudgens,Michael
在美国，相当多的青少年（13-24岁）感染了艾滋病毒，病毒载量未受抑制。艾滋病干预（ATN） 152研究[评估触发升级实时依从性（TERA）干预]基线数据进行了检查，以确定高病毒血症（bb0 5000拷贝/mL）和自我报告依从性的相关性，这有助于为病毒血症青年规划差异化服务。在这87名青年样本中，抑郁、艾滋病耻辱感和大麻使用是常见的。近一半（48%）患者有高病毒血症，这与制定的病耻感、中度至高风险酒精使用、精神健康诊断和年龄≥21岁相关。自我报告的依从性与病毒载量有关，并与精神和身体健康功能、抑郁、社会支持、自信决策、总体和内化耻辱、依从性动机以及过去6个月内错过一次护理访问的报告有关。精神健康成为病毒载量和依从性的共同关联。临床试验注册号：NCT03292432。
A sizable portion of youth (ages 13–24) living with HIV in the United States have unsuppressed viral load. The AIDS Interventions (ATN) 152 study [evaluating the Triggered Escalating Real-Time Adherence (TERA) intervention] baseline data were examined to identify correlates of high viremia (>5000 copies/mL) and self-reported adherence, which can help in planning of differentiated services for viremic youth. Depression, HIV-stigma, and cannabis use were common in this sample of 87 youth. Almost half (48%) had high viremia, which associated with enacted stigma, moderate- to high-risk alcohol use, mental health diagnosis, and age ≥21. Self-reported adherence was related to viral load and associated with mental and physical health functioning, depression, social support, self-confident decision-making, total and internalized stigma, adherence motivation, and report of a missed a care visit in the past 6 months. Mental health emerged as a common correlate of viral load and adherence. Clinical Trial Registration number: NCT03292432.