The Promise of Self-Assembled 3D Supramolecular Coordination Complexes for Biomedical Applications
The Promise of Self-Assembled 3D Supramolecular Coordination Complexes for Biomedical Applications
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DOI：
10.1021/acs.inorgchem.7b02599
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发表时间：
2017-12-18
影响因子：
4.6
通讯作者：
Wenzel, Margot
中科院分区：
文献类型：
--
作者：
Casini, Angela;Woods, Benjamin;Wenzel, Margot
在超分子化学领域，配位驱动的自组装已经为许多分支学科的巨大发展提供了基础，从关于新结构的设计和合成的基础研究到定义不同的实际应用。在这一框架内，超分子配位络合物(SCCs)是由较小的离子金属节点和有机多齿配体的前体构建块形成的大型化学实体，导致复杂和定义明确的超分子结构，具有巨大的前景。值得注意的是，人们对构建离散的3D分子结构的兴趣已经经历了非凡的进展，因为它们在传感器、催化剂、探针和容器以及基础主客体化学中具有潜在的应用前景。尽管有大量的合成努力和许多固有的良好特性，但3D SCCs在生物医学应用领域仍处于初级阶段。这一观点侧重于3D SCCs，特别是金属离子和螺旋结构，首先简要介绍其主客体性质的合成和表征方面的基本原理，然后通过具有代表性的例子概述可能的生物应用。因此，将特别强调金属阳离子作为药物输送系统和手性螺旋作为DNA识别结构域。总体而言，我们将提供最新的最新文献，并将在不同学科的交界处定义这一引人入胜的研究领域的挑战。
In the supramolecular chemistry field, coordination-driven self-assembly has provided the basis for tremendous growth across many subdisciplines, spanning from fundamental investigations regarding the design and synthesis of new architectures to defining different practical applications. Within this framework, supramolecular coordination complexes (SCCs), defined as large chemical entities formed from smaller precursor building blocks of ionic metal nodes and organic multidentate ligands, resulting in intricate and well-defined supra molecular structures, hold great promise. Notably, interest in the construction of discrete 3D molecular architectures, such as those offered by SCCs, has experienced extraordinary progress because of their potential application as sensors, catalysts, probes, and containers and in basic host guest chemistry. Despite numerous synthetic efforts and a number of inherent favorable properties, the field of 3D SCCs for biomedical applications is still in its infancy. This Viewpoint focuses on 3D SCCs, specifically metallacages and helicates, first briefly presenting the fundamentals in terms of the synthesis and characterization of their host guest properties, followed by an overview of the possible biological applications with representative examples. Thus, emphasis will be given in particular to metallacages as drug delivery systems and to chiral helicates as DNA recognition domains. Overall, we will provide an update on the state-of-the-art literature and will define the challenges in this fascinating research area at the interface of different disciplines.