TIM-3 and CEACAM1 are Prognostic Factors in Head and Neck Squamous Cell Carcinoma.
TIM-3 and CEACAM1 are Prognostic Factors in Head and Neck Squamous Cell Carcinoma.
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TIM-3和CEACAM1是头颈鳞状细胞癌中的预后因素。
DOI：
10.3389/fmolb.2021.619765
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发表时间：
2021
影响因子：
5
通讯作者：
Wei F
中科院分区：
文献类型：
--
作者：
Yang F;Zeng Z;Li J;Ren X;Wei F
背景资料：T细胞免疫球蛋白和粘蛋白结构域包含分子-3（TIM-3）是一种新的免疫检查点分子，在调节免疫应答和诱导免疫耐受中起着重要而复杂的作用。TIM-3在活化的T细胞上表达，并且其在细胞毒性T细胞上的信号传导导致T细胞耗竭，这由癌胚抗原相关细胞粘附分子1（CEACAM 1）介导，CEACAM 1是在肿瘤组织和/或肿瘤浸润淋巴细胞（TIL）上表达的另一种众所周知的分子。 研究方法：在本研究中，我们研究了TIM-3和CEACAM 1在80例头颈部鳞状细胞癌（HNSCC）标本中的免疫组化表达，并与详细的结果、临床病理参数相关联。本文报告了TIM-3+/CEACAM 1 + TIL的评分和绝对计数，并评估了肿瘤组织中CEACAM 1的表达。 结果如下：结果显示，更多的TIM-3+ TIL浸润与较差的总体存活相关（p < 0.001），癌细胞上CEACAM 1的存在（p < 0.001）和肿瘤微环境中CEACAM 1 + TIL的存在（p = 0.015）也是如此。多因素考克斯回归分析显示，高TIM-3+ TIL可能被认为是疾病预后不良的独立预后因素（风险比，2.066; 95%置信区间，1.027-4.159; p = 0.042），以及癌细胞表达CEACAM 1水平（风险比，5.885; 95%置信区间，2.832-12.230; p < 0.001）。 结论：我们的结果表明，TIM-3和CEACAM 1的表达可能代表了一个高度功能失调的T细胞群体。本研究结果提示，这两项指标均为有价值的预测指标，可为临床设计有效的头颈部肿瘤免疫治疗方案提供参考。
Background: T-cell Immunoglobulin and Mucin domain-containing molecule-3 (TIM-3) is a new immune checkpoint molecule which plays important and complex roles in regulating immune responses and in inducing immune tolerance. TIM-3 is expressed on activated T cells and its signaling on cytotoxic T cells leads to T cell exhaustion which is mediated by carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), another well-known molecule expressed on tumor tissues and/or tumor infiltrating lymphocytes (TILs). Methods: In the present study, we investigated TIM-3 and CEACAM1 immunohistochemical expression in 80 head and neck squamous cell carcinoma (HNSCC) specimens, linked to detailed outcome, clinic-pathological parameters. Here we reported scores and absolute counts of TIM-3+/CEACAM1+ TILs, and evaluated the expression of CEACAM1 on tumor tissues. Results: The results showed that more TIM-3+ TILs infiltration correlated with poorer overall survival (p < 0.001), as did the presence of CEACAM1 on cancer cells (p < 0.001) and CEACAM1+ TILs in tumor microenvironment (p = 0.015). Multivariate Cox regression analysis revealed that high TIM-3+ TILs may be considered as an independent prognostic factor of poor disease outcome (hazard ratio, 2.066; 95% confidence interval, 1.027–4.159; p = 0.042), as well as cancer cells expressed CEACAM1 level (hazard ratio, 5.885; 95% confidence interval, 2.832–12.230; p < 0.001). Conclusion: Our results indicate that expression of TIM-3 and CEACAM1 may represent a highly dysfunctional population of T cells. Our current findings suggest both of them were valuable predicting markers that might provide help for clinicians to design effective immunotherapeutic regimen against head and neck carcinoma.