Estimation of fiber orientation and spin density distribution by diffusion deconvolution
Estimation of fiber orientation and spin density distribution by diffusion deconvolution
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DOI：
10.1016/j.neuroimage.2010.11.087
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发表时间：
2011-04-01
期刊：
影响因子：
5.7
通讯作者：
Tseng, Wen-Yih Isaac
中科院分区：
文献类型：
--
作者：
Yeh, Fang-Cheng;Wedeen, Van Jay;Tseng, Wen-Yih Isaac
提出了一种扩散反卷积方法，将反卷积应用于扩散取向分布函数（dODF）并计算纤维取向分布函数（fODF），其被定义为纤维自旋密度的取向分布。dODF可以从诸如q球成像（QBI）、扩散谱成像（DSI）和广义q采样成像（GQI）的q空间成像方法获得，因此该方法可以应用于各种扩散采样方案。进行体模研究以比较fODF与dODF的角分辨率，并使用单壳、双壳和网格采样方案获取体内数据集，然后分别通过QBI、GQI和DSI重建。体模研究表明，在45度和60度交叉角下，fODF的角分辨率显著优于dODF。体内研究表明，无论采用何种采样方案和重建方法，fODF都是一致的，并且在减少采样条件下，分辨交叉纤维的能力有所提高。从反卷积获得的纤维自旋密度显示出比分数各向异性（FA）映射更高的对比度噪声比，并在纤维束成像的进一步应用表明，纤维自旋密度可用于确定纤维束的终止。总之，所提出的反卷积方法一般适用于不同的q空间成像方法。计算的fODF提高了角分辨率，并且还提供了纤维自旋密度的定量指标以细化纤维跟踪。(C)2011 Elsevier Inc. All rights reserved.
A diffusion deconvolution method is proposed to apply deconvolution to the diffusion orientation distribution function (dODF) and calculate the fiber orientation distribution function (fODF), which is defined as the orientation distribution of the fiber spin density. The dODF can be obtained from q-space imaging methods such as q-ball imaging (QBI), diffusion spectrum imaging (DSI), and generalized q-sampling imaging (GQI), and thus the method can be applied to various diffusion sampling schemes. A phantom study was conducted to compare the angular resolution of the fODF with the dODF, and the in vivo datasets were acquired using single-shell, two-shell, and grid sampling schemes, which were then reconstructed by QBI, GQI, and DSI, respectively. The phantom study showed that the fODF significantly improved the angular resolution over the dODF at 45- and 60-degree crossing angles. The in vivo study showed consistent fODF regardless of the applied sampling schemes and reconstruction methods, and the ability to resolve crossing fibers was improved in reduced sampling condition. The fiber spin density obtained from deconvolution showed a higher contrast-to-noise ratio than the fractional anisotropy (FA) mapping, and further application on tractography showed that the fiber spin density can be used to determine the termination of fiber tracts. In conclusion, the proposed deconvolution method is generally applicable to different q-space imaging methods. The calculated fODF improves the angular resolution and also provides a quantitative index of fiber spin density to refine fiber tracking. (C) 2011 Elsevier Inc. All rights reserved.