Experimental Trypanosoma cruzi myocarditis: relative effects upon the right and left ventricles.
Experimental Trypanosoma cruzi myocarditis: relative effects upon the right and left ventricles.
复制标题
实验性克氏锥虫心肌炎：对右心室和左心室的相对影响。
DOI：
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发表时间：
1969
影响因子：
6
通讯作者：
W. Abelmann
中科院分区：
文献类型：
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作者：
R. Kumar;I. Kline;W. Abelmann
1964年，该实验室报道了由一株克氏锥虫（哥伦比亚）产生的C3H小鼠实验性心脏病的特点和病程虽然最初相对轻微，但随后的寄生虫传代已经看到这种实验性心肌病在急性和慢性阶段变得越来越严重早期充血性心力衰竭从来不会自发发生，但可以通过某些干预措施引起。”在第100次传代后，可以观察到持续的心力衰竭。因此，一个已知自然原因的充血性心力衰竭的实验模型首次可供研究。本报告描述了这种模式，分析了左右心室的相对参与，并讨论了对人类恰加斯病某些表现的发病机制的影响。
IN 1964 the characteristics and course of experimental heart disease in C3H mice produced by a strain of Trypanosoma cruzi (Colombian) were reported from this laboratory.2 Although relatively mild initially, subsequent passages of the parasite have seen this experimental cardiomyopathy become increasingly severe both in the acute and the chronic phase.3 In early passages congestive heart failure never occurred spontaneously but could be induced by certain interventions." After the 100th passage heart failure could be observed consistently. For the first time, then, an experental model of congestive heart failure of known natural cause became available for study. The present report characteries this model, analyzes the relative involvenent of the right and left ventricles, and discusses the implications for the pathogenesis of certain manifestation of Chagas' disease in man.