SCREENING FOR CONGENITAL HYPO-THYROIDISM - RESULTS IN NEWBORN POPULATION OF NEW ENGLAND
SCREENING FOR CONGENITAL HYPO-THYROIDISM - RESULTS IN NEWBORN POPULATION OF NEW ENGLAND
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DOI：
10.1001/jama.239.22.2348
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发表时间：
1978-01-01
影响因子：
120.7
通讯作者：
MADOFF, MA
中科院分区：
文献类型：
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作者：
MITCHELL, ML;LARSEN, PR;MADOFF, MA
在手术的第一年，新英格兰地区甲状腺功能减退筛查项目测定了129028名出生在康涅狄格州、缅因州、马萨诸塞州、新罕布什尔州和罗德岛州（美国）的婴儿滤纸上干血中的甲状腺素（T4）水平。约3800例新生儿标本中T4水平低于正常下限（< 6.0 .mu）。g/dl)，测定促甲状腺激素（TSH）含量。TSH水平升高（0.20 μ m）。U/ml)，其中23例最终证实为明确的甲状腺功能减退。根据这些数据，包括2名未接受检测的甲状腺功能减退婴儿，新英格兰地区先天性甲状腺功能减退症的发病率约为1:52 200。对T4值低的标本进行T4值估算，并辅以TSH值测定，是大规模筛查先天性甲状腺功能减退症的一种满意方法。
During the 1st yr of operation, the New England Regional Hypothyroidism Screening Program determined the concentration of thyroxine (T4) levels in dried blood on filter paper from 129,028 infants born in Connecticut, Maine, Massachusetts, New Hampshire and Rhode Island [USA]. Specimens from approximately 3800 neonates had levels of T4 below the lower limit of normal (< 6.0 .mu.g/dl) and were assayed for thyroid-stimulating hormone (TSH) content. Levels of TSH were elevated (> 20 .mu.U/ml) in 31 infants, 23 of whom eventually proved to have unequivocal hypothyroidism. Based on these figures and including 2 hypothyroid infants who were not tested, the incidence of congenital hypothyroidism in the New England region is approximately 1:5200 births. The estimation of T4 values supplemented by measurement of TSH values on specimens with low T4 values proved to be a satisfactory approach to large-scale screening for congenital hypothyroidism.