Control of a cluster of community-associated, methicillin-resistant Staphylocloccus aureus in neonatology
Control of a cluster of community-associated, methicillin-resistant Staphylocloccus aureus in neonatology
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DOI：
10.1016/j.jhin.2005.11.016
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发表时间：
2006-05-01
影响因子：
6.9
通讯作者：
Pittet, D.
中科院分区：
文献类型：
--
作者：
Sax, H.;Posfay-Barbe, K.;Pittet, D.
为了控制社区相关性MRSA （CA-MRSA）在新生儿病房的爆发，进行了一项调查，包括筛查新生儿和父母，MRSA分离株的分子分析和病例的长期随访。在2000年夏季的两个月期间，在5名新生儿中检测到产生潘通-瓦伦丁杀白细胞素（PVL）的CA-MRSA （ST5-MRSA-IV菌株）。指数病例的母亲表现出乳腺炎和伤口感染的迹象，因此CA-MRSA检测呈阳性。一个小。地方性pvl阴性MRSA菌株（st228 -MRSA- 1）同时发生。加强卫生措施，屏障预防，局部。携带者的非殖民化和新入院者的集合终止了疫情。疫情爆发4个月后，另一名新生儿的母亲感染了流行的CA-MRSA菌株并发疖病。一名婴儿在爆发四年后持续携带CA-MRSA导致其兄弟姐妹皮肤感染。结论：CA-MRSA流行菌株是由指示病例的母亲引入的。这种病毒在新生儿中传播，并随后传染给另一位母亲和一个兄弟姐妹。这是欧洲首次成功控制新生儿爆发的遗传上不同的产生pvl的CA-MRSA。(c) 2006年，医院感染学会。Elsevier Ltd.出版。版权所有。
To control an outbreak of community-associated MRSA (CA-MRSA) in a neonatology unit, an investigation was conducted that involved screening neonates and parents, molecular analysis of MRSA isolates and tong-term follow-up of cases. During a two-month period in the summer of 2000, Panton-Valentine leukocidin (PVL)-producing CA-MRSA (strain ST5-MRSA-IV) was detected in five neonates. The mother of the index caseshowed signs of mastitis and wound infection and consequently tested positive for CA-MRSA. A small. cluster of endemic, PVL-negative MRSA strains (ST228-MRSA-I) occurred in parallel. Enhanced hygiene measures, barrier precautions, topical. decolonization of carriers, and cohorting of new admissions terminated the outbreak. Four months after the outbreak, the mother of another neonate developed furunculosis with the epidemic CA-MRSA strain. One infant had persistent CA-MRSA carriage resulting in skin infection in a sibling four years after the outbreak. In conclusion, an epidemic CA-MRSA strain was introduced by the mother of the index case. This spread among neonates and was subsequently transmitted to another mother and a sibling. This is the first report of a successfully controlled neonatology outbreak of genetically distinct PVL-producing CA-MRSA in Europe. (c) 2006 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.