Complement activation in the injured central nervous system: another dual-edged sword?
Complement activation in the injured central nervous system: another dual-edged sword?
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DOI：
10.1186/1742-2094-9-137
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发表时间：
2012-06-21
影响因子：
9.3
通讯作者：
Ruitenberg MJ
中科院分区：
文献类型：
--
作者：
Brennan FH;Anderson AJ;Taylor SM;Woodruff TM;Ruitenberg MJ
补体系统是先天免疫系统的主要组成部分，越来越多地被认为是生理学和疾病的关键参与者。人们意识到免疫介质支持正常中枢神经系统(CNS)功能和病理的各个方面，这导致了神经科学中补体研究的复兴。各种研究揭示了补体在神经发育、突触消除和神经网络成熟中的广泛参与，以及在一系列慢性神经退行性疾病和最近的神经创伤事件中的病理进展，其中迅速破坏神经元稳态可能触发补体激活。本文就补体激活与后天性脑或脊髓损伤，即脑缺血再灌注损伤或卒中、创伤性脑损伤(TBI)和脊髓损伤(SCI)的最新研究结果进行综述，重点介绍补体靶向治疗在减轻这些神经系统疾病的破坏性后果方面的潜力。
The complement system, a major component of the innate immune system, is becoming increasingly recognised as a key participant in physiology and disease. The awareness that immunological mediators support various aspects of both normal central nervous system (CNS) function and pathology has led to a renaissance of complement research in neuroscience. Various studies have revealed particularly novel findings on the wide-ranging involvement of complement in neural development, synapse elimination and maturation of neural networks, as well as the progression of pathology in a range of chronic neurodegenerative disorders, and more recently, neurotraumatic events, where rapid disruption of neuronal homeostasis potently triggers complement activation. The purpose of this review is to summarise recent findings on complement activation and acquired brain or spinal cord injury, i.e. ischaemic-reperfusion injury or stroke, traumatic brain injury (TBI) and spinal cord injury (SCI), highlighting the potential for complement-targeted therapeutics to alleviate the devastating consequences of these neurological conditions.
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DOI：
10.4049/jimmunol.1102310
发表时间：
2012-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Banda NK;Hyatt S;Antonioli AH;White JT;Glogowska M;Takahashi K;Merkel TJ;Stahl GL;Mueller-Ortiz S;Wetsel R;Arend WP;Holers VM
通讯作者：
Holers VM
DOI：
10.4049/jimmunol.0903678
发表时间：
2010-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Amara U;Flierl MA;Rittirsch D;Klos A;Chen H;Acker B;Brückner UB;Nilsson B;Gebhard F;Lambris JD;Huber-Lang M
通讯作者：
Huber-Lang M
靶向补体抑制剂可预防移植后心脏缺血和再灌注损伤，并揭示补体激活替代途径的重要作用
影响因子：
4.4
作者：
Atkinson, Carl;He, Songqing;Tomlinson, Stephen
通讯作者：
Tomlinson, Stephen
影响因子：
56.9
作者：
ALPER, CA;JOHNSON, AM;MOORE, FD
通讯作者：
MOORE, FD
影响因子：
4.2
作者：
Bellander, BM;Singhrao, SK;Svensson, M
通讯作者：
Svensson, M