Updates on the risk markers and outcomes of severe juvenile idiopathic arthritis-associated uveitis.
Updates on the risk markers and outcomes of severe juvenile idiopathic arthritis-associated uveitis.
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DOI：
10.2217/ijr.12.83
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发表时间：
2013-02-01
期刊：
影响因子：
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通讯作者：
Vogler LB
中科院分区：
文献类型：
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作者：
Angeles-Han ST;Yeh S;Vogler LB
葡萄膜炎是幼年特发性关节炎最常见的关节外表现，是儿童葡萄膜炎最常见的全身性病因。已知的葡萄膜炎危险因素包括抗核抗体血清阳性、关节炎发病年龄小、特定的幼年特发性关节炎亚型和病程短。严重眼部疾病的风险标志包括初次就诊时的性别、年龄和并发症。由于视力损害后遗症的风险，如白内障，带状角膜病变，青光眼，视力丧失和失明，了解葡萄膜炎发展和严重眼部疾病的风险因素对于帮助预防严重的视力残疾和并发症至关重要。本文综述了葡萄膜炎的发病机制，已知的危险因素葡萄膜炎的发展和严重的视觉结果，并解决了需要额外的生物标志物葡萄膜炎的风险，预后和缓解。
Uveitis is the most common extra-articular manifestation of juvenile idiopathic arthritis, which is the most common systemic cause of uveitis in children. Known risk factors for uveitis include antinuclear antibody seropositivity, young age of arthritis onset, specific juvenile idiopathic arthritis subtype and short duration of disease. Risk markers for severe ocular disease include gender, age and complications at initial visit. Due to the risk for vision-compromising sequelae such as cataracts, band keratopathy, glaucoma, vision loss and blindness, an understanding of the risk factors for uveitis development and severe ocular disease is crucial to help prevent serious visual disability and complications. This paper reviews the pathogenesis of uveitis, known risk factors for uveitis development and severe visual outcome, and addresses the need for additional biomarkers of uveitis risk, prognosis and remission.