Impact of patient-specific LVOT inflow profiles on aortic valve prosthesis and ascending aorta hemodynamics
Impact of patient-specific LVOT inflow profiles on aortic valve prosthesis and ascending aorta hemodynamics
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DOI：
10.1016/j.jocs.2017.11.005
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发表时间：
2018-01-01
影响因子：
3.3
通讯作者：
Goubergrits, Leonid
中科院分区：
文献类型：
--
作者：
Bruening, Jan;Hellmeier, Florian;Goubergrits, Leonid
患者特异性模型在心血管研究中变得越来越重要，因为它们可以预测外科手术。虽然左心室流出轮廓是一个基本的边界条件，但在治疗前仍是未知的。为了克服这一问题，虚拟瓣膜置换术后的血液动力学计算基于左心室流出道的不同入口轮廓：一个通用的塞子轮廓和一个来自4D-flow-MRI的轮廓。主动脉内的空间平均参数没有显着改变使用任何一个配置文件。通用的配置文件可能足以预测血液动力学，避免预测患者特定边界条件的变化的问题。(C)2017爱思唯尔B. V.保留所有权利。
Patient-specific models become increasingly important in cardiovascular research as they allow prediction of surgical procedures. While the left ventricular outflow profile is an essential boundary condition, it remains unknown before treatment takes place. To overcome this problem, hemodynamics after virtual valve replacement were calculated based on different inlet profiles at the left ventricular outflow tract: a generic plug profile and a profile derived from 4D-flow-MRI. Spatially averaged parameters within the aorta were not significantly altered using either profile. A generic profile might be sufficient for the prediction of hemodynamics, circumventing the problem of predicting change in patient-specific boundary conditions. (C) 2017 Elsevier B.V. All rights reserved.