OMA Browser - Exploring orthologous relations across 352 complete genomes
OMA Browser - Exploring orthologous relations across 352 complete genomes
复制标题
DOI：
10.1093/bioinformatics/btm295
复制
发表时间：
2007-08-15
期刊：
影响因子：
5.8
通讯作者：
Gonnet, Gaston H.
中科院分区：
文献类型：
--
作者：
Schneider, Adrian;Dessimoz, Christophe;Gonnet, Gaston H.
动机：蛋白质之间进化关系的推断，特别是同源基因的鉴定，是比较基因组学的核心问题。使用各种方法和范围的几个大型项目解决了这个问题，包括OMA （Orthologous MAtrix项目）。结果：基于OMA项目的结果，我们在这里介绍OMA浏览器，这是一个基于网络的工具，允许探索352个完整基因组的同源关系。同源物可以被看作是跨物种的群体，但也可以在序列对的水平上，允许区分一对一，一对多和多对多的同源物。可用性：http://omabrowser.orgContact: schneadr@inf.ethz.ch
Motivation: Inference of the evolutionary relation between proteins, in particular the identification of orthologs, is a central problem in comparative genomics. Several large-scale efforts with various methodologies and scope tackle this problem, including OMA ( the Orthologous MAtrix project).Results: Based on the results of the OMA project, we introduce here the OMA Browser, a web-based tool allowing the exploration of orthologous relations over 352 complete genomes. Orthologs can be viewed as groups across species, but also at the level of sequence pairs, allowing the distinction among one-to-one, one-to-many andmany-to- many orthologs.Availability: http://omabrowser.orgContact: schneadr@inf.ethz.ch