AGE-RELATED MACULAR DEGENERATION AND CHOROIDAL NEOVASCULARIZATION
AGE-RELATED MACULAR DEGENERATION AND CHOROIDAL NEOVASCULARIZATION
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DOI：
10.1016/s0002-9394(14)73649-9
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发表时间：
1993-06-15
影响因子：
4.2
通讯作者：
SORENSON, JA
中科院分区：
文献类型：
--
作者：
FREUND, KB;YANNUZZI, LA;SORENSON, JA
年龄相关性黄斑变性的新生血管变异可在临床试验建立的明确指导方针内进行激光光凝治疗。然而，只有有限数量的患者符合这种治疗方式的资格标准，主要是因为常见的脉络膜新生血管定义不清或隐匿性。先前的研究估计，一半的新生血管性年龄相关性黄斑变性患者在疾病的初始表现时有隐匿的新生血管。我们检查了67例新诊断的单侧新生血管性年龄相关性黄斑变性患者的初步发现。这些患者中87%（67人中58人）的疾病不符合黄斑光凝研究组的激光光凝治疗指南。由于很少有患者有资格进行激光光凝治疗，因此进一步研究诊断和治疗这种疾病的新技术是必要的。
The neovascular variant of age-related macular degeneration is amenable to laser photocoagulation treatment within well-defined guidelines established by clinical trials. However, only a limited number of patients meet eligibility criteria for this form of treatment, principally because of the ill-defined, or occult nature, of the choroidal neovascularization commonly seen. Previous studies have estimated that one half of patients with neovascular age-related macular degeneration have occult neovascularization at initial manifestation of the disease. We examined the initial findings of 67 patients with newly diagnosed unilateral neovascular age-related macular degeneration. Eighty-seven percent of these patients (58 of 67) had disease that did not meet Macular Photocoagulation Study Group guidelines for laser photocoagulation treatment. As so few patients are eligible for laser photocoagulation, further research into new techniques of diagnosis and treatment for this disorder is warranted.