Four-dimensional velocity-encoded magnetic resonance imaging improves blood flow quantification in patients with complex accelerated flow
Four-dimensional velocity-encoded magnetic resonance imaging improves blood flow quantification in patients with complex accelerated flow
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DOI：
10.1002/jmri.23793
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发表时间：
2013-01-01
影响因子：
4.4
通讯作者：
Kuehne, Titus
中科院分区：
文献类型：
--
作者：
Nordmeyer, Sarah;Riesenkampff, Eugenie;Kuehne, Titus
目的：探讨四维（4D）速度编码磁共振成像（VEC MRI）对半月瓣狭窄合并复杂血流加速患者血流定量的应用价值。材料与方法：对志愿者（n = 7）和半月瓣狭窄患者（n = 18）进行二维和四维VEC MRI定量测定峰值流速（Vmax）和脑卒中容积（SV）。使用这两种技术在主动脉和肺动脉瓣上方进行测量，此外，在4D数据集中的升主动脉和肺动脉干的多个预定义平面上进行测量。在患者中，4D VEC MRI流线分析确定了血流模式和最高血流速度区域（4dmax目标），以便进一步测量，并通过多普勒超声心动图测量Vmax。结果：在患者中，4D VEC MRI显示的Vmax高于2D VEC MRI (2.7 +/- 0.6 m/s vs. 2.4 +/- 0.5 m/s, P < 0.03)，与多普勒超声心动图（2.8 +/- 0.7 m/s）更具可比性。4Dmax-targeted的Vmax值最高（3.1 +/- 0.6 m/s）。SV测量结果显示，复杂加速血流患者升主动脉不同解剖水平之间存在显著差异，而层流模式志愿者的差异可以忽略不计（P = 0.004）。结论：4D VEC MRI提高了半月瓣狭窄和复杂血流加速患者MRI血流定量。j .增效。的原因。成像2013;37:208216。(c) 2012 Wiley期刊有限公司
Purpose: To evaluate the use of four-dimensional (4D) velocity-encoded magnetic resonance imaging (VEC MRI) for blood flow quantification in patients with semilunar valve stenosis and complex accelerated flow. Materials and Methods: Peak velocities (Vmax) and stroke volumes (SV) were quantified by 2D and 4D VEC MRI in volunteers (n = 7) and patients with semilunar valve stenosis (n = 18). Measurements were performed above the aortic and pulmonary valve with both techniques and, additionally, at multiple predefined planes in the ascending aorta and in the pulmonary trunk within the 4D dataset. In patients, 4D VEC MRI streamline analysis identified flow patterns and regions of highest flow velocity (4Dmax-targeted) for further measurements and Vmax was also measured by Doppler-echocardiography. Results: In patients, 4D VEC MRI showed higher Vmax than 2D VEC MRI (2.7 +/- 0.6 m/s vs. 2.4 +/- 0.5 m/s, P < 0.03) and was more comparable to Doppler-echocardiography (2.8 +/- 0.7 m/s). 4Dmax-targeted revealed highest Vmax values (3.1 +/- 0.6 m/s). SV measurements showed significant differences between different anatomical levels in the ascending aorta in patients with complex accelerated flow, whereas differences in volunteers with laminar flow patterns were negligible (P = 0.004). Conclusion: 4D VEC MRI improves MRI-derived blood flow quantification in patients with semilunar valve stenosis and complex accelerated flow. J. Magn. Reson. Imaging 2013;37:208216. (c) 2012 Wiley Periodicals, Inc.