Dual‐Responsive Supramolecular Antimicrobial Coating Based on Host‐Guest Recognition
Dual‐Responsive Supramolecular Antimicrobial Coating Based on Host‐Guest Recognition
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DOI：
10.1002/admi.202201209
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发表时间：
2022-08
影响因子：
5.4
通讯作者：
Yiting Wang;Gangyang Wang;Yifeng Ni;Jiahui Zhou;Shuaibing Wang;Yucong Gu;D. Zhang;S. Zheng
中科院分区：
文献类型：
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作者：
Yiting Wang;Gangyang Wang;Yifeng Ni;Jiahui Zhou;Shuaibing Wang;Yucong Gu;D. Zhang;S. Zheng
细菌在生物医学表面的粘附和增殖对患者造成了极大的威胁。开发一类具有优良细菌释放能力的可再生杀菌表面对于延长生物医学设备的使用寿命至关重要。然而，快速和频繁地释放细菌通常是彻底释放它们并完全再生表面的权衡。在此，开发了温度/光双响应抗菌涂层。将含环糊精（CD）的大分子和含热响应性偶氮苯的大分子组装在CD改性的表面上，与另外的银纳米颗粒组合。表面显示出9.30 × 105个细胞cm−2的低细菌附着（E.大肠杆菌，120 h），杀菌率高达96.3%。同时，约86.9%的附着细菌可以响应于温度而从表面快速释放，并且残留物可以通过照射UV照射而被彻底去除（释放率约91.0%）。表面的功能可以通过光调节切换主客体网络来恢复。第三次再生表面仍保持12.4 × 105个细胞cm-2的低细菌密度，细菌杀灭率为105.0%，细菌释放率为105.7%。该工作为多功能抗菌表面的设计提供了新的思路，并拓宽了其应用领域。
The adhesion and proliferation of the bacteria on biomedical surfaces have posed a great threat to patients. Developing a class of renewable bactericidal surface with excellent bacteria release capability is crucial for elongating the service life of the biomedical devices. However, releasing the bacteria fast and frequently is usually a trade‐off with releasing them thoroughly and completely regenerating the surface. Herein, a temperature/light dual‐responsive antimicrobial coating is developed. The cyclodextrin (CD)‐contained antifouling macromolecule and the thermal‐responsive azobenzene‐contained macromolecule are assembled on the CDs‐modified surface, combined with additional silver nanoparticles. The surface exhibits low bacteria attachments of 9.30 × 105 cells cm−2 (E. coli, 120 h), high bactericidal efficiency of ≈96.3%. Meanwhile, ≈86.9% of the attached bacteria can be released from the surface rapidly in response to temperature, and the residues can be thoroughly removed by irradiating UV irradiation (release ratio ≈91.0%). The functions of the surface can be resumed by switching the host‐guest network via light regulation. The 3rd regenerated surface still maintains low bacteria density of 12.4 × 105 cells cm−2, bacteria killing ratio of ≈95.0%, and bacteria release rate of ≈95.7%. The work is supposed to provide a new insight into the design of multifunctional antibacterial surface and broaden their applications.