Genetic and environmental influences on sleep quality in middle-aged men: a twin study.
Genetic and environmental influences on sleep quality in middle-aged men: a twin study.
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遗传和环境对中年男性睡眠质量的影响：一项双胞胎研究。
DOI：
10.1111/jsr.12048
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发表时间：
2013-10
影响因子：
4.4
通讯作者：
Lyons MJ
中科院分区：
文献类型：
--
作者：
Genderson MR;Rana BK;Panizzon MS;Grant MD;Toomey R;Jacobson KC;Xian H;Cronin-Golomb A;Franz CE;Kremen WS;Lyons MJ
睡眠质量差是许多认知和生理年龄相关疾病的风险因素。识别睡眠质量的潜在因素对于理解这些与年龄相关的健康疾病的病因非常重要。我们使用经典双胞胎设计调查了基因和环境对中年男性双胞胎主观睡眠质量的影响程度。我们使用匹兹堡睡眠质量指数（PSQI）测量了1218名来自越南时代双胞胎衰老研究（VETSA）的中年双胞胎男性的睡眠质量（平均年龄=55.4岁，范围51-60岁；339对同卵双胞胎，257对异卵双胞胎，26对未配对双胞胎）。PSQI整体平均评分为5.6 （SD=3.6，范围0-20）。基于单变量双胞胎模型，全球PSQI评分中34%的变异性是由于加性遗传效应（遗传性），66%归因于个体特定的环境因素。共同环境对变异没有贡献。同样，睡眠质量差的遗传性——基于全球睡眠质量指数（PSQI）临界值的二分法——为31%，没有共同环境的影响。七项PSQI成分评分（主观睡眠质量、睡眠潜伏期、睡眠持续时间、习惯性睡眠效率、睡眠障碍和日间功能障碍）中六项的遗传率范围从。15到。31，没有基因影响导致使用睡眠药物。累加性遗传影响约占全球主观睡眠质量可变性的三分之一。我们对中年男性的研究结果是研究睡眠和衰老其他方面的遗传关系的第一步。
Poor sleep quality is a risk factor for a number of cognitive and physiological age-related disorders. Identifying factors underlying sleep quality are important in understanding the etiology of these age-related health disorders. We investigated the extent to which genes and the environment contribute to subjective sleep quality in middle-aged male twins using the classical twin design. We used the Pittsburgh Sleep Quality Index (PSQI) to measure sleep quality in 1218 middle-aged twin men from the Vietnam Era Twin Study of Aging (VETSA)(mean age=55.4 years; range 51–60; 339 monozygotic twin pairs, 257 dizygotic twin pairs, 26 unpaired twins). The mean PSQI global score was 5.6 (SD=3.6; range 0–20). Based on univariate twin models, 34% of variability in the global PSQI score was due to additive genetic effects (heritability) and 66% was attributed to individual-specific environmental factors. Common environment did not contribute to the variability. Similarly, the heritability of poor sleep—a dichotomous measure based on the cut-off of global PSQI>5--was 31% with no contribution of the common environment. Heritability of six of the seven PSQI component scores (Subjective Sleep Quality, Sleep Latency, Sleep Duration, Habitual Sleep Efficiency, Sleep Disturbances, and Daytime Dysfunction) ranged from .15 to .31, where as no genetic influences contributed to Use of Sleeping Medication. Additive genetic influences contribute to approximately one-third of the variability of global subjective sleep quality. Our results in middle-aged men constitute a first step toward examination of the genetic relationship between sleep and other facets of aging.