Telomere attrition in lens epithelial cells - a target for N-acetylcarnosine therapy
Telomere attrition in lens epithelial cells - a target for N-acetylcarnosine therapy
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DOI：
10.2741/3655
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发表时间：
2010-06-01
影响因子：
3.1
通讯作者：
Yegorov, Yegor E.
中科院分区：
文献类型：
--
作者：
Babizhayev, Mark A.;Yegorov, Yegor E.
透镜上皮细胞特别容易受到氧化应激的影响。人透镜上皮细胞中端粒酶活性缺失导致的端粒的破坏和缩短已被认为是导致透镜过早衰老的主要原因。肌肽，从N-乙酰肌肽前体润滑剂滴眼液中眼内释放，在生理浓度下可能显著降低在缺乏有效的抗氧化剂透镜保护的情况下经受氧化应激的透镜细胞中端粒缩短的速率。与对照组相比，接受1% N-乙酰肌肽润滑剂滴眼液治疗的老年成人受试者和老年白内障受试者的视功能（视力、眩光敏感度）数据显示出显著改善，对照组的视功能通常无改善，视力和眩光敏感度读数与基线无差异。用眼用前药N-乙酰肌肽预防细胞衰老可能是白内障管理、基本预防保健和囊外白内障摘除术后后发性白内障的新治疗靶点。
The lens epithelium is especially vulnerable to oxidative stress. The erosion and shortening of telomeres in human lens epithelial cells in the lack of telomerase activity has been recognized as a primary cause of premature lens senescence phenotype that trigger human cataractogenesis. Carnosine, released ophthalmically from N-acetylcarnosine prodrug lubricant eye drops, at physiological concentration might remarkably reduce the rate of telomere shortening in the lens cells subjected to oxidative stress in the lack of efficient antioxidant lens protection. The data of visual functions (visual acuity, glare sensitivity) in older adult subjects and older subjects with cataract treated with 1% N-acetylcarnosine lubricant eye drops showed significant improvement as compared, by contrast with the control group which showed generally no improvement in visual functions, with no difference from baseline in visual acuity and glare sensitivity readings. Prevention of cellular senescence with ophthalmic prodrug N-acetylcarnosine may be a novel therapeutic target in a management of cataract, basic preventive health care and in arresting of after-cataract following extracapsular cataract extraction.