A retinohypothalamic pathway in man: Light mediation of circadian rhythms
A retinohypothalamic pathway in man: Light mediation of circadian rhythms
复制标题
人类视网膜下丘脑通路：昼夜节律的光调节
DOI：
10.1016/0006-8993(84)90252-x
复制
发表时间：
1984
期刊：
影响因子：
2.9
通讯作者：
Lois E. H. Smith
中科院分区：
文献类型：
--
作者：
A. Sadun;J. Schaechter;Lois E. H. Smith
It has been proposed that, in animals, a retinohypothalamic pathway exists which mediates the synchronization of the diurnal lightdark cycle with the central neural components regulating endogenous rhythms. There have been numerous anatomic, physiologic and behavioral investigations to substantiate this proposed connection in experimental animals.Morphologic investigation of a retinohypothalamic tract in man has awaited the development of a technique capable of axonal tracing in the human brain. The paraphenylenediamine method was applied to 7 post-mortem human brains. Degenerated axons were found in the suprachiasmatic nuclei of the hypothalamus in each of the 4 patients who had incurred prior optic nerve damage. The retinosuprachiasmatic pathway may be the anatomical substrate for the integration of retinal light information with endogenous rhythms in man.
