Retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy for stage III and IV oral cancer: Analysis of therapeutic results in 112 cases
Retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy for stage III and IV oral cancer: Analysis of therapeutic results in 112 cases
复制标题
DOI：
10.1016/j.radonc.2014.03.005
复制
发表时间：
2014-05-01
影响因子：
5.7
通讯作者：
Tohnai, Iwai
中科院分区：
文献类型：
--
作者：
Mitsudo, Kenji;Koizumi, Toshiyuki;Tohnai, Iwai
目的：目的：探讨逆行超选择动脉内化疗加每日同步放疗治疗Ⅲ、Ⅳ期口腔癌的疗效及器官保存率。材料与方法：112例Ⅲ、Ⅳ期口腔鳞癌患者行动脉内放化疗。从颞浅动脉和枕动脉进行导管插入。治疗包括超选择性动脉内化疗（多西他赛，总60 mg/m2，顺铂，总150 mg/m2）和每日同步放疗（总60戈伊）6 wk.Results：所有患者的中位随访时间为46.2个月（范围，10-76个月）。动脉内放化疗后，98例（87.5%）原发部位完全缓解。5年生存率和局部控制率分别为71.3%和79.3%。3级或4级毒性包括92.0%的粘膜炎、30.4%的中性粒细胞减少、28.6%的皮炎、26.8%的贫血和7.1%的血小板减少。3级毒性包括吞咽困难72.3%，恶心/呕吐21.4%，发热8.0%，肾功能衰竭0.9%的patients.Conclusion：逆行超选择动脉内化疗和每日同步放射治疗III期和IV期口腔癌提供了良好的总体生存和局部控制。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Purpose: To evaluate the therapeutic results and rate of organ preservation in patients with stage III or IV oral cancer treated with retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy.Materials and methods: One hundred and twelve patients with stage III and IV oral squamous cell carcinoma underwent intra-arterial chemoradiotherapy. Catheterization from the superficial temporal and occipital arteries was performed. Treatment consisted of superselective intra-arterial chemotherapy (docetaxel, total 60 mg/m(2), cisplatin, total 150 mg/m(2)) and daily concurrent radiotherapy (total of 60 Gy) for 6 weeks.Results: The median follow-up for all patients was 46.2 months (range, 10-76 months). After intra-arterial chemoradiotherapy, primary site complete response was achieved in 98 (87.5%) of 112 cases. Five-year survival and local control rates were 71.3% and 79.3%, respectively. Grade 3 or 4 toxicities included mucositis in 92.0%, neutropenia in 30.4%, dermatitis in 28.6%, anemia in 26.8%, and thrombocytopenia in 7.1% of patients. Grade 3 toxicities included dysphagia in 72.3%, nausea/vomiting in 21.4%, fever in 8.0%, and renal failure in 0.9% of patients.Conclusion: Retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy for stage III and IV oral cancer provided good overall survival and local control. (C) 2014 Elsevier Ireland Ltd. All rights reserved.