One-pot synthesis of highly magnetically sensitive nanochains coated with a highly cross-linked and biocompatible polymer.
One-pot synthesis of highly magnetically sensitive nanochains coated with a highly cross-linked and biocompatible polymer.
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DOI：
10.1002/anie.201003820
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发表时间：
2010-11
影响因子：
--
通讯作者：
Junfeng Zhou;L. Meng;Xinliang Feng;Xiaoke Zhang;Q. Lu
中科院分区：
文献类型：
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作者：
Junfeng Zhou;L. Meng;Xinliang Feng;Xiaoke Zhang;Q. Lu
纳米粒子的组织和功能化成为分级有序的纳米材料，由于其独特的结构和它们的电子，[1]光学，[2]和磁性而引起了极大的兴趣。[3]在所使用的合成技术中，将磁性纳米颗粒组织成一维（1D）纳米结构对于基础研究和实际应用都特别有趣。[3]已经提出了两种基本策略来获得1D磁性纳米结构，包括使用纳米结构模板[4]或通过受控的自组装过程。[5]对于后一种方法，磁偶极定向组装代表了一种制造磁性链状结构的通用方法。[5a]然而，由于磁性构建块之间的各向异性偶极相互作用很弱或可以忽略不计，这些有序结构在去除外场后很难保持。[5e]在这方面，尽管已经使用了定义明确的嵌段共聚物[3]或末端官能聚合物[5 b，d]来稳定1D磁链，但它们在用良溶剂冲洗期间会发生崩解。[6]交联聚合物壳能够解决这一障碍，[6]但这些有机交联表面活性剂的合成复杂且耗时。[7]然而，开发一种简单的方法来直接获得用交联聚合物涂覆的1D磁性纳米链仍然是有吸引力的。在此，我们提出了一个简单的一锅法合成的一维磁性纳米链涂有高度交联的聚合物。基于Fe 3 O 4的胶体纳米团簇（CNCs）由于顺磁性和显著的磁响应的组合而被选择作为一维纳米链的构建块。[8]选择高度交联的聚合物聚（-环三磷腈-co-4，4 '-磺酰基双酚）（PZS）作为一维纳米链稳定和功能化的外壳，它赋予纳米链良好的水分散性、生物相容性和定制的表面化学。[9]由于一维组装和PZS涂层，纳米链显示出增强的磁共振（MR）灵敏度和生物相容性。CNCs@ PZS纳米链的合成在方案1中示出。Fe 3 O 4 CNCs首先根据本发明制备。
The organization and functionalization of nanoparticles into hierarchically ordered nanomaterials has attracted great interest because of their unique structures and their electronic,[1] optical,[2] and magnetic properties.[3] Among the synthetic techniques used, organization of magnetic nanoparticles into one-dimensional (1D) nanostructures is particularly intriguing for both fundamental research and practical applications.[3] Two basic strategies have been proposed to obtain 1D magnetic nanostructures, including the use of nanostructured templates [4] or through a controlled selfassembly process.[5] For the latter approach, magnetic dipole-directed assembly represents a versatile method to fabricate magnetic chainlike structures.[5a] However, owing to the weak or negligible anisotropic dipolar interaction between the magnetic building blocks, these ordered structures can hardly be maintained after removal of the external field.[5e] In this regard, although well-defined block copolymers [3] or endfunctional polymers [5b, d] have been utilized to stabilize 1D magnetic chains, they suffer from disintegration during rinsing with a good solvent.[6] Cross-linked polymeric shells are able to tackle this obstacle,[6] but the synthesis of these organic cross-linkable surfactants are complicated and time-consuming.[7] The development of a facile method to directly obtain 1D magnetic nanochains coated with cross-linked polymers is however still attractive. Herein we present a facile one-pot synthesis of 1D magnetic nanochains coated with highly cross-linked polymer. Fe3O4-based colloidal nanocrystal clusters (CNCs) were selected as building blocks for 1D nanochains owing to the combination of paramagnetism and remarkable magnetic response.[8] The highly cross-linked polymer poly (-cyclotriphosphazene-co-4, 4’-sulfonyldiphenol)(PZS) was chosen as the shell for the stabilization and functionalization of the 1D nanochains, and it endows the nanochains good water dispersibility, biocompatibility, and tailored surface chemistry.[9] On account of the 1D assembly and the PZS coating, the nanochains display an enhanced magnetic resonance (MR) sensitivity and biocompatiblility. The synthesis of CNCs@ PZS nanochains is illustrated in Scheme 1. The Fe3O4 CNCs were first prepared according to a