Brain lesion size and location: Effects on motor recovery and functional outcome in stroke patients
Brain lesion size and location: Effects on motor recovery and functional outcome in stroke patients
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DOI：
10.1053/mr.2000.3837
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发表时间：
2000-04-01
影响因子：
4.3
通讯作者：
Wong, MK
中科院分区：
文献类型：
--
作者：
Chen, CL;Tang, FT;Wong, MK
目的：探讨脑损伤的档案，结合大小和位置对运动恢复和功能的结果中风后偏瘫patients.Design的影响：划定大小（阈值病变大小）的5个主要位置被确定为建立脑损伤档案的基础上，磁共振成像结果中风后1个月。运动和功能结果与脑损伤轮廓和其他脑损伤因素相关，以确定最主要的因素。设置：医疗中心，康复科。参与者：55例偏瘫患者。主要结果测量：Brunnstrom分期和功能独立性测量（Findability Measure，FIELD）评分在卒中后1个月和6个月进行评估。结果：皮质、辐射冠、内囊、壳核和丘脑区域的界限尺寸分别设定为75、4、0.75、22和12厘米（3），脑损伤轮廓在确定最终Brunnstrom分期（斯皮尔曼氏rho = 0.861，p <0.01）和Brunnstrom评分（斯皮尔曼氏rho = 0.571，p <0.01）中起主要作用。Brunnstrom的和ESTA分数没有或只有弱负相关的绝对或相对病变size.Conclusions：这些研究结果可能表明，运动和功能的结果中风后与脑病变的配置文件（划界大小和主要位置的组合）比绝对或相对病变大小。根据原发病灶位置的不同，确定最终结局的界限大小有显著差异。
Objective: To investigate effects of brain lesion profiles that combined sizes and locations on motor recovery and functional outcome after stroke in hemiplegic patients.Design: Delimiting sizes (a threshold lesion size) of 5 primary locations were identified to establish brain lesion profiles based on magnetic resonance imaging findings 1 month after stroke. Motor and functional outcome were correlated with brain lesion profiles and other brain lesion factors to identify the most dominant factor.Setting: Medical center, rehabilitation department.Participants: Fifty-five hemiplegic patients.Main Outcome Measures: Brunnstrom's stages and Functional Independence Measure (FIM) scores were assessed 1 and 6 months after stroke.Results: With delimiting sizes for the cortical, corona radiata, internal capsule, putaminal, and thalamic regions set at 75, 4, .75, 22, and 12cm(3), respectively, brain lesion profiles play a dominant role in determining final Brunnstrom's stages (Spearman's rho = .861, p < .01) and FIM score (Spearman's rho = .571, p < .01). Brunnstrom's and FIM scores had no or only weak negative relationship with either absolute or relative lesion size.Conclusions: These findings may suggest that motor and functional outcomes after stroke correlate with brain lesion profiles (a combination of delimiting sizes and primary locations) more than with absolute or relative lesion sizes only. Delimiting sizes in determining final outcomes varied markedly according to the primary lesion locations.