Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors
Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors
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DOI：
10.1021/ol0517269
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发表时间：
2005-09-29
期刊：
影响因子：
5.2
通讯作者：
Mobashery, S
中科院分区：
文献类型：
--
作者：
Lee, M;Bernardo, MM;Mobashery, S
化合物1,2 -(4-phenoxyphenyisulfonylmethyl)thiirane是一种选择性明胶酶抑制剂，在癌症转移和中风的动物模型研究中显示出很高的前景。(R)-1和(S)-1对映体；化合物1分别在本研究中合成，并被证明对明胶酶具有同样的抑制作用。
Compound 1, 2-(4-phenoxyphenyisulfonylmethyl)thiirane, is a selective inhibitor of gelatinases, which is showing high promise in studies of animal models for cancer metastasis and stroke. The (R)-1 and (S)-1 enantiomers; of compound 1 were each synthesized in this study and were shown to be equally active in inhibition of gelatinases.